{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:21:08Z","timestamp":1792110068037,"version":"4.4.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Symptomatic irreversible pulpitis often results in heightened reactions to thermal stimuli such as pain evoked by a cold stimulus, and spontaneous odontogenic pain (unprovoked pain).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study primarily compared the clinical manifestations of odontogenic spontaneous pain and pain provoked by cold stimulus specifically focusing on their sensory discriminative characteristics (intensity, duration and quality) between symptomatic irreversible pulpitis patients with and without referred pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010three patients with symptomatic irreversible pulpitis with referred pain and 12 patients without referred pain were included in this cross\u2010sectional study. The following outcomes were assessed: odontogenic spontaneous pain and its descriptors; pain evoked by cold stimulus and qualitative sensory testing before and after local anaesthesia; referred pain location; use of analgesic medication; complementary anaesthesia efficacy.\n                      <jats:italic>T<\/jats:italic>\n                      \u2010test, chi\u2010squared and McNemar tests were applied to the data (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.50).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with referred pain presented a greater odontogenic pain intensity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05) when considered the average of the last 24\u2009h. These patients also showed higher pain rating and pain descriptors (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). Intensity and duration of the pain evoked by cold stimulus in the non\u2010affected contralateral tooth at baseline were higher for patients with referred pain (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Symptomatic irreversible pulpitis patients with referred pain present greater odontogenic spontaneous pain and a heightened pain sensitivity. Therefore, patients with referred pain seem more complex from a pain severity perspective, supporting the clinical utility of discriminating symptomatic irreversible pulpitis with and without referred pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13725","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:49:05Z","timestamp":1716770945000},"page":"1589-1598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Referred pain is associated with greater odontogenic spontaneous pain and a heightened pain sensitivity in patients with symptomatic irreversible pulpitis"],"prefix":"10.1111","volume":"51","author":[{"given":"Paulo Roberto Jara","family":"de Souza","sequence":"first","affiliation":[{"name":"Department of Dentistry, Endodontics, and Dental Materials, Bauru School of Dentistry University of S\u00e3o Paulo  Bauru S\u00e3o Paulo 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