{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:12:18Z","timestamp":1775193138318,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004488","name":"Hrvatska Zaklada za Znanost","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004488","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Single nucleotide polymorphisms (SNPs) may influence pain susceptibility and impact treatment response in pain\u2010related temporomandibular disorders (TMDp).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Explore the role of <jats:italic>COMT<\/jats:italic> (rs4646310, rs6269, rs4818, rs4680) and <jats:italic>OPRM1<\/jats:italic> (rs1799971) genotypes in regulating treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty TMDp patients (55 females and 5 males), diagnosed with the Diagnostic Criteria for TMD (DC\/TMD), underwent standardised treatment (information and education, home physical therapy, occlusal splint) for 6\u2009months. Treatment outcomes included: pain intensity, pain\u2010free mouth opening, jaw functional limitation, depression, and anxiety. Genotyping for <jats:italic>COMT<\/jats:italic> and <jats:italic>OPRM1<\/jats:italic> SNPs was performed using DNA from buccal mucosa swabs and TaqMan assays. Statistical analysis was carried out to compare the changes in treatment outcomes and the influence of genotypes on treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly less pain reduction was observed in minor allele carriers of rs4646310, and rs4680 compared to dominant homozygous (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.025). Minor allele carriers of rs1799971 and rs4646310 demonstrated worsening in pain\u2010free mouth opening while dominant homozygous exhibited improvement (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.025). Significantly less anxiety reduction was observed in minor allele carriers of rs4646310 compared to dominant homozygous (<jats:italic>p<\/jats:italic>\u2009=\u2009.003).<\/jats:p><jats:p>Of the all variables assessed in the regression model, carrying a minor allele of rs1799971 predicted a poorer treatment response considering pain\u2010free mouth opening while carrying a minor allele of rs4646310 predicted less pain and less anxiety reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that certain SNP variants of the <jats:italic>COMT<\/jats:italic> and <jats:italic>OPRM1<\/jats:italic> genes were associated with poorer treatment response and may therefore play a significant role in the classification of TMDp patients. Also, assessment of patient genotype could potentially aid in predicting treatment response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.13730","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T01:13:25Z","timestamp":1715303605000},"page":"1542-1554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genetic influence on treatment outcomes in patients with pain\u2010related temporomandibular disorders"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4532-0839","authenticated-orcid":false,"given":"Marko","family":"Zlendi\u0107","sequence":"first","affiliation":[{"name":"Department of Removable Prosthodontics University of Zagreb School of Dental Medicine  Zagreb 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