{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:17:22Z","timestamp":1776788242181,"version":"3.51.2"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Occlusal disharmony (OD) may induce anxiety\u2010like behaviours; however, the underlying mechanism remains unclear. Herein, we explored the expression profiles of non\u2010coding RNAs (ncRNAs), along with their biological function and regulatory network, in anxiety\u2010like behaviour induced by OD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Occlusal disharmony was produced by anterior crossbite of C57BL\/6 mice. Behavioural tests, corticosterone (CORT) and serotonin (5\u2010HT) levels were used to measure anxiety. In addition, RNA sequencing was used to screen all differentially expressed (DE) ncRNAs. Moreover, the RNA\u2010binding proteins interacting with ncRNAs were predicted by the ENCORI database and confirmed using western blots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The significant differences in behavioural tests and CORT suggested the successful induction of anxiety\u2010like behaviour by OD. In OD mice, ncRNAs were significantly dysregulated. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses suggested that the DE ncRNAs were enriched in anxiety\u2010related pathways. CircRNA10039 was upregulated, and PTBP1 was predicted to interact with circRNA10039. In addition, KEGG pathway analysis showed that PTBP1 may be associated with messenger RNA biogenesis and spliceosomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OD induced by anterior crossbite can lead to the anxiety\u2010like behaviours. During this process, ncRNA also changes. CircRNA10039 and PTBP1 may play a role in OD\u2010induced anxiety\u2010like behaviours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13816","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T04:24:37Z","timestamp":1721881477000},"page":"2248-2260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non\u2010coding RNA alterations in occlusal disharmony\u2010induced anxiety\u2010like behaviour"],"prefix":"10.1111","volume":"51","author":[{"given":"Mi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oral Maxillofacial\u2010Head Neck Oncology Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wu","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University  Fuzhou China"},{"name":"Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihui","family":"Zhang","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxuan","family":"Li","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6879-6525","authenticated-orcid":false,"given":"Jiang","family":"Chen","sequence":"additional","affiliation":[{"name":"School and Hospital of Stomatology Fujian Medical University  Fuzhou China"},{"name":"Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology Fujian Medical University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2014.12.025"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjq121"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.09.020"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18037-y"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.08.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18081687"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.02.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034517708771"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(98)00079-4"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.03.020"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13136"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2016.06.004"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0448-z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0038-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.268969"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2016.1255398"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.744251"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7505260"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2021.100347"},{"key":"e_1_2_9_21_1","volume-title":"American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM\u20105\u2122","author":"Arlington VA","year":"2013"},{"issue":"5","key":"e_1_2_9_22_1","first-page":"e1","volume":"117","year":"2017","journal-title":"J Prosthet Dent"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00653-0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojrm.2018.71001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.05.079"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1014338"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2016.08.002"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12060747"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.12.020"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00378-3"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800121301"},{"issue":"4","key":"e_1_2_9_32_1","first-page":"5103","article-title":"Paeoniflorin improves menopause depression in ovariectomized rats under chronic unpredictable mild stress","volume":"8","author":"Huang H","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.120"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/026988110001400204"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.01.038"},{"issue":"2","key":"e_1_2_9_36_1","first-page":"173","article-title":"Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects","volume":"38","author":"Mechawar N","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.118"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111244"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301574"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.04.021"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.02.018"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2021.09.019"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.03.027"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7590997"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0902-18.2018"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1114066"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.13816","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T01:19:21Z","timestamp":1728955161000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.13816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":45,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/joor.13816"],"URL":"https:\/\/doi.org\/10.1111\/joor.13816","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOOR.13816\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13816\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13816\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13816\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13816\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13816\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.13816\/v3\/response1","asserted-by":"object"}]},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,25]]},"assertion":[{"value":"2023-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}