{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:22:49Z","timestamp":1780377769765,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Aberrant occlusion and aging are two main risks for temporomandibular joint (TMJ) degeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the combined impact of occlusion and age on TMJ disc.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      To avoid the confounding impact of gender, presently, 126 female C57BL\/6J mice, 63 youngsters, 6\u2010week old and 63 adults, 28\u2010week old, were used. An experimental bilateral anterior crossbite (BAC) relation was created by installing metal tubes onto the mandibular incisors. Mice were sacrificed at 3, 7 and 11\u2009weeks (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099). Additionally, the installed tubes were removed at 7\u2009weeks in removal groups and the TMJs were sampled after another 4\u2009weeks (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099). Disc changes were detected by histomorphology, immunohistochemistry, and western blot assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Disc deformation was obvious in BAC groups. The typical change was hyperplasia at the posterior region of the disc where there was significant infiltration of inflammatory cells. Expressions of the inflammatory markers, including tumour necrosis factor\u2010\u03b1 and interleukin\u20101\u03b2, and the catabolic markers, including fibronectin (FN), FN N\u2010terminal fragments, and vascular endothelial growth factor\u2010A, were all increased. The changes were more obvious in adults than in youngsters. Removal of BAC attenuated inflammatory and catabolic changes in the youngsters, but the inflammatory markers recovered little in the adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TMJ disc responds to BAC by degeneration and inflammation, and respond to BAC removal by rehabilitation. Adult discs show severer degeneration responses to BAC and a lower level of anti\u2010inflammatory capability to BAC removal than the youngster's discs. Animals cannot be equated with humans. The human disc response to occlusion changes worth further exploration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13833","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:34:03Z","timestamp":1723509243000},"page":"2503-2512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Temporomandibular joint disc responses to installation and removal of the experimental malocclusion"],"prefix":"10.1111","volume":"51","author":[{"given":"Yuejiao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Oral Anatomy and Physiology, Shanghai Stomatological Hospital and School of Stomatology Fudan University  Shanghai China"},{"name":"Department of Oral Anatomy and Physiology and TMD, School of Stomatology Fourth Military Medical University  Xi'an 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