{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T10:09:57Z","timestamp":1787306997361,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuroplasticity induced by mandibular advancement appliance (MAD) in patients with obstructive sleep apnoea (OSA) is poorly documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This randomised placebo\u2010controlled crossover mechanistic study assessed the effects of short\u2010term use of a MAD on corticomotor excitability of the masseter and tongue in patients with OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Adults (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928) with mild or moderate OSA were randomly allocated to sleep with a MAD for 2\u2010weeks with 40% of the maximal protrusion (MAD active position) and without any jaw protrusion (MAD placebo position). The outcomes were assessed at baseline, and after 2 and 6\u2009weeks, with a 2\u2010week washout period. The primary outcome was the amplitude of motor evoked potential (MEP) assessed on the right masseter, right side of tongue and right first dorsal interosseous with transcranial magnetic stimulation. Corticomotor map volume of the same muscles was also assessed. Repeated\u2010measures ANOVAs followed by Tukey test were applied to the data (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.050).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a significant increase in the MEP amplitude of the masseter and tongue following the MAD active position compared with the baseline and MAD placebo (Tukey:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001). There were no significant MEP amplitude differences between the baseline and placebo positions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u2009.050). Moreover, there was a significant increase in corticomotor map volume for the masseter and tongue muscles following the MAD active position compared with baseline and MAD placebo (Tukey:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Excitability of the masseter and tongue motor pathways is, at least transiently, increased in patients with OSA following a short\u2010term use of MAD. This novel finding of MAD\u2010induced neuroplasticity in corticomotor pathways may contribute to a further understanding of the mechanisms of oral appliances for treating OSA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13846","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T02:24:09Z","timestamp":1726885449000},"page":"2600-2610","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact of a mandibular advancement device on corticomotor plasticity in patients with obstructive sleep apnea"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-5020","authenticated-orcid":false,"given":"Yuri M.","family":"Costa","sequence":"first","affiliation":[{"name":"Department of Biosciences Universidade Estadual de Campinas (UNICAMP), Faculdade de Odontologia de Piracicaba (FOP)  Piracicaba Brazil"},{"name":"Section for Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"},{"name":"Scandinavian Center for Orofacial Neurosciences  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Hayakawa","sequence":"additional","affiliation":[{"name":"Section for Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"},{"name":"Scandinavian Center for Orofacial Neurosciences  Aarhus Denmark"},{"name":"Department of Prosthodontics Bauru School of Dentistry, University of Sao Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1109-2364","authenticated-orcid":false,"given":"Eduardo. 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