{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:36:43Z","timestamp":1790213803219,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760202"],"award-info":[{"award-number":["81760202"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inhibition of astrocytic energy metabolism alleviates neuropathic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore whether astrocyte\u2010neuron lactate shuttle (ANLS) played any role in neuropathic orofacial pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats with partial transection of the right infraorbital nerve (p\u2010IONX) or sham operation were intrathecally injected with acetazolamide (a carbonic anhydrase inhibitor), bithionol (a soluble adenylyl cyclase inhibitor), \u03b1\u2010cyano\u20104\u2010hydroxycinnamic acid [\u03b1\u2010CHCA, a monocarboxylate transporter (MCT) inhibitor] or vehicle once a day from postoperative day 1\u201314. The facial mechanical thresholds were tested on preoperative day 1 and 2 and postoperative days 1, 3, 5, 7, 10 and 14, expression of glucose transporters (GLUTs) and MCTs in the trigeminal subnucleus caudalis (Vc) were examined on the postoperative day 3 and neuronal activities in the Vc were examined in the p\u2010IONX rats on postoperative days 3\u20135.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the sham group, the mechanical thresholds in the p\u2010IONX group were significantly reduced at postoperative days 1\u20137, and the number of astrocytes expressing GLUT1 and MCT1\/4, and neurons expressing MCT2 was significantly increased on postoperative day 3. In the p\u2010IONX groups, neurons in the Vc were sensitised, and acetazolamide, bithionol and \u03b1\u2010CHCA reversed the central sensitisation, significantly increased the mechanical thresholds at postoperative days 1\u20137 and decreased the number of astrocytes expressing GLUT1 and MCT1\/4, and neurons expressing MCT2 at postoperative day 3 compared with those in the vehicle\u2010treated rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Inhibition of ANLS alleviates p\u2010IONX\u2010related neuronal, behavioural and immunohistochemical changes, which suggests that ANLS plays an important role in trigeminal neuropathic pain.<\/jats:p>\n                  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