{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:13:29Z","timestamp":1790158409081,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271013"],"award-info":[{"award-number":["82271013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Condylar fractures (CFs) are a common type of maxillofacial trauma, especially in adolescents. Conservative treatment of CF avoids the possible complications of surgical intervention, but prolongs the patient's suffering because of the requirement for extended intermaxillary fixation. Therefore, the development of a new strategy to accelerate the rate of fracture healing to shorten the period of conservative treatment is of great clinical importance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the potential of deferoxamine (DFO) in promoting the healing process of CF in adolescent mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010two 4\u2010week\u2010old male C57BL\/6J mice were randomly assigned to four groups: vehicle\u2009+\u2009sham group, vehicle\u2009+\u2009CF group, DFO\u2009+\u2009sham group and DFO\u2009+\u2009CF group. After constructing the mandibular CF model, mandibular tissue samples were collected respectively at 1, 2 and 4\u2009weeks postoperatively. Radiographic and histomorphometric analyses were employed to assess bone tissue healing and vascular formation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Deferoxamine was observed to promote the early bone healing of fracture, both radiologically and histomorphometrically. Furthermore, this enhancement of condylar neck fracture healing was attributed to the upregulation of the hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1) signalling pathway while facilitating the formation of type H vessels. In addition, DFO did not produce significant effects on the condylar neck between vehicle\u2009+\u2009sham and DFO\u2009+\u2009sham group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The application of the HIF\u20101\u03b1 inducer DFO can enhance type H vessels expansion thereby accelerating condylar neck fracture healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13869","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:29:13Z","timestamp":1728001753000},"page":"17-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Deferoxamine Accelerates Mandibular Condylar Neck Fracture Early Bone Healing by Promoting Type H Vessel\u00a0Proliferation"],"prefix":"10.1111","volume":"52","author":[{"given":"Sijia","family":"Leng","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Stomatological Hospital and Dental School of Tongji University  Shanghai China"},{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Cong","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Stomatological Hospital and Dental School of Tongji University  Shanghai China"},{"name":"Shanghai Engineering Research Center of Tooth Restoration and Regeneration  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxing","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Stomatological Hospital and Dental School of Tongji University  Shanghai 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