{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:39:11Z","timestamp":1784565551211,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite the high levels of success after orthognathic surgery, the immediate postoperative pain and edema, besides the neurosensorial deficits, are common complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the pattern of sensory and inflammatory responses in patients undergoing orthognathic surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational study included 20 patients undergoing bimaxillary orthognathic surgery, who were evaluated in the preoperative period and on Days 1, 2, 3, 4, 5, 6, 7, and 30 after surgery, using a battery of tests to assess sensorial and inflammatory changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Subjective and objective evaluations of edema indicated a trend toward edema resolution within 30\u2009days, with a significant decrease in mouth opening on days 1, 7, and 30 after surgery. Regarding nasal obstruction, a significant increase in Nasal Obstruction Symptom Evaluation (NOSE) scores was demonstrated on the first, second, and third days, returning to preoperative levels after 30\u2009days. There was a significant increase in visual analogic scale (VAS) scores from the first to the seventh day after surgery, with a reduction within 30\u2009days. For mechanical and thermal sensitivity tests, the lower lip and chin regions had poorer results, without recovery after 30\u2009days. Positive correlations were observed between painful and inflammatory parameters, as well as between subjective and objective evaluations. Analysis of saliva biomarkers did not show significant differences for pre\u2010 and postoperative CCL3 or CCL4 levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Data provide new evidence about the early inflammatory and sensorial complications after orthognathic surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13871","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:25:25Z","timestamp":1728001525000},"page":"420-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Screening of Sensorial and Inflammatory Changes in Patients Submitted to Orthognathic Surgery"],"prefix":"10.1111","volume":"52","author":[{"given":"Ta\u00edse","family":"Simonetti","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o Em Odontologia, Escola de Ci\u00eancias da Sa\u00fade e da Vida Pontif\u00edcia Universidade Cat\u00f3lica Do Rio Grande Do Sul  Porto Alegre Rio Grande Do Sul Brazil"},{"name":"Centro de Pesquisa Em Toxicologia e Farmacologia, Escola de Ci\u00eancias da Sa\u00fade e da Vida Pontif\u00edcia Universidade Cat\u00f3lica Do Rio Grande Do Sul  Porto Alegre Rio Grande Do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa A.","family":"Tomasi","sequence":"additional","affiliation":[{"name":"Centro de Pesquisa Em Toxicologia e Farmacologia, Escola de Ci\u00eancias da Sa\u00fade e da Vida Pontif\u00edcia Universidade Cat\u00f3lica Do Rio Grande Do Sul  Porto Alegre Rio Grande Do Sul Brazil"},{"name":"Cursos de Gradua\u00e7\u00e3o Em Biomedicina e Farm\u00e1cia, Escola de Ci\u00eancias da Sa\u00fade e da Vida Pontif\u00edcia Universidade Cat\u00f3lica Do Rio Grande Do Sul  Porto Alegre Rio Grande Do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme G.","family":"Fritscher","sequence":"additional","affiliation":[{"name":"Ambulat\u00f3rio de Cirurgia Oral, Escola de Ci\u00eancias da Sa\u00fade e da Vida Pontif\u00edcia Universidade Cat\u00f3lica Do Rio Grande Do Sul  Porto Alegre Rio Grande Do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7738-9892","authenticated-orcid":false,"given":"Maria M.","family":"Campos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o Em Odontologia, Escola de Ci\u00eancias da Sa\u00fade e da Vida Pontif\u00edcia Universidade Cat\u00f3lica Do Rio Grande Do Sul  Porto Alegre Rio Grande Do Sul Brazil"},{"name":"Centro de Pesquisa Em Toxicologia e Farmacologia, Escola de Ci\u00eancias da Sa\u00fade e da Vida Pontif\u00edcia Universidade Cat\u00f3lica Do Rio Grande Do Sul  Porto Alegre Rio Grande Do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192316028"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-4220(57)80063-2"},{"key":"e_1_2_12_4_1","first-page":"42","article-title":"Retromolar Osteotomy for the Correction of Prognathism","volume":"19","author":"Dal Pont G.","year":"1961","journal-title":"Journal of Oral Surgery, Anesthesia, and Hospital Dental Service"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000003839"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2019.03.329"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.15-0670"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13225"},{"key":"e_1_2_12_9_1","first-page":"1","article-title":"Safety of Metamizole (Dipyrone) for the Treatment of Mild to Moderate Pain\u2010An Overview of Systematic Reviews","author":"Eleut\u00e9rio O. 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