{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:13:54Z","timestamp":1791810834543,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7174364"],"award-info":[{"award-number":["7174364"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate conditioned pain modulation (CPM) in burning mouth syndrome (BMS) patients with different pain mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Twenty BMS patients (52.0\u2009\u00b1\u20096.8\u2009years, 17 women and 3 men) and age\u2010 and gender\u2010matched 22 healthy controls were enrolled in this randomised controlled trial. The patients received an active lingual nerve block (lidocaine) and a placebo injection (saline) randomly with an interval of 1\u2009week in a double\u2010blinded manner. Patients evaluated their pain intensity on a 0\u2010 to 10\u2010cm visual analogue scale (VAS) before and after each injection, with or without CPM. Based on the anaesthesia effect, BMS patients were divided into two groups with presumed different pain mechanisms; a \u2018central subgroup (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911)\u2019 with pain relief less than 1\u2009cm and \u2018peripheral subgroup (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20099)\u2019 with pain relief more than 1\u2009cm on the VAS. Mechanical pain threshold (MPT) and wind\u2010up ratio (WUR) were investigated at two oral mucosa regions: the region with most intense symptoms and a control region for the patient group; tongue and buccal region for the control group. CPM was induced by immersing the left hand into cold water. A moderate level of pain (around five on the VAS) was obtained by adjusting the water temperature. MPT and WUR were measured twice for all the participants with and without CPM, which was analysed and presented as relative change in MPT and WUR. Differences between groups were analysed using two\u2010way ANOVA. Differences within group between tests were assessed by paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, there were no significant group differences for MPT or WUR between BMS patients and healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2265\u20090.156). The mean bath temperature to evoke moderate pain for the BMS group was significantly lower than that for the healthy control group (8.9\u00b0C vs. 11.9\u00b0C,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003). The CPM evoked an inhibitory modulation in 18.2%\u201344.4% of BMS patients, while for the healthy group, the ratio was 68.2%\u201381.8%. Central BMS patients had smaller CPM effects than healthy participants at the painful site and control site, which indicated a decreased CPM function (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.034). Peripheral BMS patients had lower CPM effects than healthy participants only at the painful site (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present findings documented impairment of central nociceptive inhibition processing in BMS patients which was more extensive in central BMS than peripheral BMS. These findings add to the suggestion that BMS may a heterogeneous pain condition with at least two different phenotypes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13876","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T21:21:30Z","timestamp":1730755290000},"page":"443-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Conditioned Pain Modulation Differences in Central and Peripheral Burning Mouth Syndrome (\n                    <scp>BMS<\/scp>\n                    ) Patients"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4358-7307","authenticated-orcid":false,"given":"Guangju","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Prosthodontics and Center for Oral Functional Diagnosis, Treatment and Research Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Key Laboratory of Digital Stomatology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiu","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Peking University School and Hospital of Stomatology  Beijing China"},{"name":"Department of Stomatology, Beijing Hospital, National Center of Gerontology Institute of Geriatric Medicine, Chinese Academy of Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelun","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Sensory\u2013Motor Interaction (SMI), Department of Health Science and Technology Aalborg University  Aalborg Denmark"},{"name":"Section for Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health Aarhus University  Aarhus 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