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Limited knowledge exists on dental and oral health in patients with adult\u2010onset HPP (aHPP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate oro\u2010dental characteristics in patients with aHPP compared to healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2010control study included 20 patients with aHPP compared to 31 healthy controls. Oro\u2010dental manifestations were examined by standardised interviews, clinical examinations as well as radiological registrations on panoramic radiograph (OP) and cone\u2010beam computed tomography (CBCT) scans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The subjective experience of tooth fractures (<jats:italic>p<\/jats:italic>\u2009=\u20090.010), caries in permanent teeth (<jats:italic>p<\/jats:italic>\u2009=\u20090.032) and early loss of permanent teeth (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) was significantly higher in patients with aHPP compared to the controls. In the aHPP group, the presence of specific teeth (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.045) and attrition of 11 were significantly lower (<jats:italic>p<\/jats:italic>\u2009=\u20090.012) compared to the controls. Opacity of a few teeth (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.049), presence of denticles (<jats:italic>p<\/jats:italic>\u2009=\u20090.024), the distance between the enamel\u2013cement junction (CEJ) and the marginal bone level at specific sites (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.021) and crown height of 11 (<jats:italic>p<\/jats:italic>\u2009=\u20090.017) were significantly higher in patients with aHPP than in healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results indicate that patients with aHPP have a subjective experience of having poorer dental health. Loss of permanent teeth, less attrition, tooth opacities, denticles and larger distance between CEJ and marginal bone level are possible oro\u2010dental findings in patients with aHPP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.13878","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T03:29:16Z","timestamp":1728703756000},"page":"64-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oro\u2010Dental Characteristics in Patients With Adult\u2010Onset Hypophosphatasia Compared to a Healthy Control Group\u2013A Case\u2010Control Study"],"prefix":"10.1111","volume":"52","author":[{"given":"Freja Fribert","family":"J\u00f8rgensen","sequence":"first","affiliation":[{"name":"Department of Odontology, Section of Orthodontics, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Hermann","sequence":"additional","affiliation":[{"name":"Resource Center for Rare Oral Diseases Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Hepp","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0320-8096","authenticated-orcid":false,"given":"Liselotte","family":"Sonnesen","sequence":"additional","affiliation":[{"name":"Department of Odontology, Section of Orthodontics, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2018.441"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-020-00732-6"},{"key":"e_1_2_10_4_1","article-title":"Diagnostik og Behandling af Hypofosfatasi","volume":"180","author":"Hepp N.","year":"2018","journal-title":"Ugeskrift for Laeger"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.33176\/AACB-19-00031"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-020-05345-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-023-06844-1"},{"key":"e_1_2_10_8_1","first-page":"191","volume-title":"Gorlin's Syndromes of the Head and Neck","author":"Hennekam R. 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