{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:33Z","timestamp":1787015553350,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2405900"],"award-info":[{"award-number":["2022YFC2405900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2405901"],"award-info":[{"award-number":["2022YFC2405901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82325012"],"award-info":[{"award-number":["82325012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870805"],"award-info":[{"award-number":["81870805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies have indicated that older adults with the symptom of dry mouth have an increased risk of death. B vitamins are strongly linked to oral and systemic health. However, the relationship among dry mouth, vitamin B2 and mortality remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to investigate the potential relationship among dry mouth, vitamin B2 and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 6183 participants from the US National Health and Nutrition Examination Survey (NHANES) 2011\u20132014 with information on dry mouth were included at baseline. 4324 normal individuals and 684 individuals with dry mouth were followed up until 31 December 2019. The Cox proportional hazard model was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations among dry mouth, vitamin B2 and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared to the population without dry mouth, the risk of all\u2010cause mortality was significantly higher in the population with dry mouth. The multivariable\u2010adjusted HR and 95% CI was 1.41 (1.05, 1.90). The intake of vitamin B2 can significantly reduce the risk of death in participants with dry mouth, but not in participants without dry mouth. The HR and 95% CI of all\u2010cause mortality in the highest vitamin B2 intake group was 0.37 (0.19, 0.73) compared to the lowest intake group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Individuals with dry mouth suffered a significantly higher risk of all\u2010cause mortality compared to those without dry mouth. Higher intake of vitamin B2 was apparently associated with a lower risk of all\u2010cause mortality in the population with dry mouth.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13892","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T07:16:06Z","timestamp":1737357366000},"page":"464-473","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Population\u2010Based Study of the Association Among Dry Mouth, Vitamin\n                    <scp>B2,<\/scp>\n                    and Mortality"],"prefix":"10.1111","volume":"52","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuailin","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"},{"name":"The Third Affiliated Hospital of Xinxiang Medical University  Xinxiang Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehui","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Tangdu Hospital; State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, School of Stomatology &amp; Shaanxi Key Laboratory of Stomatology, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Shanghai Smartee Denti\u2010Technology Co. Ltd.  Shanghai Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin R","family":"Tay","sequence":"additional","affiliation":[{"name":"The Dental College of Georgia Augusta University  Augusta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-0819","authenticated-orcid":false,"given":"Lina","family":"Niu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration &amp; National Clinical Research Center for Oral Diseases &amp; Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, School of Stomatology The Fourth Military Medical University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2021.103794"},{"key":"e_1_2_12_3_1","volume-title":"Dry Mouth, the Malevolent Symptom: A Clinical Guide","author":"Sreebny L.","year":"2010"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2007.0358"},{"issue":"6","key":"e_1_2_12_5_1","first-page":"1552","article-title":"Composition and Function of Saliva: A Review","volume":"9","author":"Fatima S.","year":"2020","journal-title":"World Journal of Pharmaceutical Sciences"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95865-z"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02629515"},{"issue":"6","key":"e_1_2_12_8_1","first-page":"S43","article-title":"Dry Mouth: More Common and Less Benign Than Thought","volume":"82","author":"Terrie Y.","year":"2016","journal-title":"Pharmacy Times"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/29375"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6842.1612"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12113380"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12337"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1145104"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/17.2.414"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2017.1247890"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2017.05.004"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-2478"},{"key":"e_1_2_12_18_1","first-page":"1","article-title":"National Health and Nutrition Examination Survey: Analytic Guidelines, 1999\u20132010","volume":"161","author":"Johnson C. 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