{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:47:58Z","timestamp":1769521678828,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2021206431"],"award-info":[{"award-number":["H2021206431"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701010"],"award-info":[{"award-number":["81701010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early treatment of mandibular advancement device (MAD) reverses the abnormal changes resulting from obstructive sleep apnoea (OSA), but the underlying mechanism is not clear. We analysed the changes of genioglossus function before and after MAD treatment in OSA rabbits and explored the mechanism of mitochondrial autophagy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen male New Zealand rabbits were randomised into three groups: the control group, Group OSA, and Group MAD. After successful modelling, all animals were induced sleep in supine positions for 4\u20136\u2009h per day for 8\u2009weeks. Cone beam computed tomography (CBCT) and polysomnography (PSG) were performed to record sleep conditions. The genioglossus contractile force and the levels of LC3\u2010I, LC3\u2010II, Beclin\u20101, PINK1 and Parkin were detected in three groups. In\u00a0vitro, C2C12 myoblast cells were cultured under normoxic or hypoxic conditions for 24\u2009h, and then the changes in mitochondrial structure and accumulation of autolysosomes were detected by transmission electron microscopy (TEM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The contractile tension of the genioglossus in Group OSA was significantly lower than that in the control group. The ratio of LC3II\/LC3I and the levels of Beclin\u20101, PINK1 and Parkin were higher in Group OSA than that in the control group. And the abnormal changes were tended to be normal after MAD treatment. The mitochondrial structure was disrupted, and the number of autolysosomes increased in C2C12 after 24\u2009h of hypoxia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MAD treatment in male rabbits may decrease the contractile tension of the genioglossus and increase the level of mitochondrial autophagy caused by OSA. And the mechanism of mitochondrial autophagy was mediated by the PINK1\/Parkin pathway in male rabbits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.13907","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T05:49:36Z","timestamp":1732686576000},"page":"343-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Mandibular Advancement Device on Genioglossus of Rabbits in Obstructive Sleep Apnea Through <scp>PINK1<\/scp>\/Parkin Pathway"],"prefix":"10.1111","volume":"52","author":[{"given":"Lishuang","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Hebei Medical University &amp; Hebei Key Laboratory of Stomatology &amp; Hebei Clinical Research Center for Oral Diseases  Shijiazhuang PR China"},{"name":"Department of Stomatology Harrison International Peace Hospital  Hengshui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3959-1442","authenticated-orcid":false,"given":"Yahui","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Hebei Medical University &amp; Hebei Key Laboratory of Stomatology &amp; Hebei Clinical Research Center for Oral Diseases  Shijiazhuang PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Ningxia People's Hospital  Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengying","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Hebei Medical University &amp; Hebei Key Laboratory of Stomatology &amp; Hebei Clinical Research Center for Oral Diseases  Shijiazhuang PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyan","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Hebei Medical University &amp; Hebei Key Laboratory of Stomatology &amp; Hebei Clinical Research Center for Oral Diseases  Shijiazhuang PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongna","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Hebei Medical University &amp; Hebei Key Laboratory of Stomatology &amp; Hebei Clinical Research Center for Oral Diseases  Shijiazhuang PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2713-0545","authenticated-orcid":false,"given":"Wenjing","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Hebei Medical University &amp; Hebei Key Laboratory of Stomatology &amp; Hebei Clinical Research Center for Oral Diseases  Shijiazhuang PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Hebei Medical University &amp; Hebei Key Laboratory of Stomatology &amp; Hebei Clinical Research Center for Oral Diseases  Shijiazhuang PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Hebei Medical University &amp; Hebei Key Laboratory of Stomatology &amp; Hebei Clinical Research Center for Oral Diseases  Shijiazhuang PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Hebei Medical University &amp; Hebei Key Laboratory of Stomatology &amp; Hebei Clinical Research Center for Oral Diseases  Shijiazhuang PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-014-9304-x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12101359"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12123935"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19095473"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2022084"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00131106"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP278433"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8412598","article-title":"Aging Induced p53\/p21 in Genioglossus Muscle Stem Cells and Enhanced Upper Airway Injury","volume":"3","author":"Zhu L. Y.","year":"2020","journal-title":"Stem Cells International"},{"key":"e_1_2_11_10_1","first-page":"1218","article-title":"Effects of Chronic Intermittent Hypoxia on Oxidative Stress and Inflammatory Response and the Interventional Roles of Adiponectin","volume":"95","author":"Pan G. Y.","year":"2015","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.906195"},{"key":"e_1_2_11_12_1","first-page":"881","article-title":"Characteristics and Clinical Significance of Genioglossus Neuromuscular Activity in Patients With Obstructive Sleep Apnea","volume":"56","author":"Zhou Y. Q.","year":"2021","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"e_1_2_11_13_1","first-page":"70","article-title":"Neuromuscular Properties of Genioglossus Activity in Healthy Adults and Obstructive Sleep Apnea Patients","volume":"53","author":"Zhou Y. Q.","year":"2018","journal-title":"Chinese Journal of Otorhinolaryngology Head and Neck Surgery"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2022.103980"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cju042"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01320-2019"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.10028"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1666-5369"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2022.05.161"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12165315"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.9308"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2020.09.043"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60034-1"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.05.025"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12040668"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201643309"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00369.2021"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cju041"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70238-0"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3028"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63274-6.00008-4"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2110"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2016.1163418"},{"key":"e_1_2_11_34_1","first-page":"300","article-title":"Effect of Mandibular Advancement Device Upon Nuclear Factor \u03baB and Tumor Necrosis Factor \u03b1, Interleukin 6 in Genioglossus of Rabbit With Obstructive Sleep Apnea Hypopnea Syndrome","volume":"52","author":"Zhang S. L.","year":"2017","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932684"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.848214"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2020.6186"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2016.05.008"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2019.1594243"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11583"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.05.007"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2008.12.010"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.13907","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T05:15:36Z","timestamp":1738559736000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.13907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,26]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/joor.13907"],"URL":"https:\/\/doi.org\/10.1111\/joor.13907","archive":["Portico"],"relation":{},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,26]]},"assertion":[{"value":"2023-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}