{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:18:05Z","timestamp":1790709485325,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T00:00:00Z","timestamp":1735430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005354","name":"Folktandv\u00e5rden, \u00d6rebro L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019032","name":"Regionala Forskningsr\u00e5det Uppsala\/\u00d6rebro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009612","name":"Landstinget V\u00e4stmanland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Botulinum toxin Type A (BTX\u2010A) is increasingly used in the management of myofascial pain; however, the evidence to support this treatment modality is still inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the change in days with functional jaw pain after one session of BTX\u2010A or placebo injections into the masseter and temporalis muscles in subjects with jaw myalgia. The hypothesis was that BTX\u2010A is effective in reducing the number of days with functional jaw pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a randomised, double\u2010blind, parallel group study in subjects with jaw myalgia. After randomisation, BTX\u2010A or placebo injections were made in the masseter and temporalis muscles. The number of days with jaw pain on function was evaluated after 2\u2009months. Adverse events were registered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010three subjects were randomly assigned to BTX\u2010A and 22 to placebo. Between baseline and the 2\u2010month follow\u2010up, the number of days with jaw pain at function changed from a median (interquartile range) of 14 (4) to 10.5 (6) days in the BTX\u2010A group and from 14.0 (1.5) to 14 (5) in the saline group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.585). Adverse events were mild and transient and similar in the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A single treatment of BTX\u2010A injections in the masseter and temporalis muscles was not effective in treating jaw myalgia. However, an adequately powered study might provide sufficient support for efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13915","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T01:26:03Z","timestamp":1735521963000},"page":"587-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect on Pain Following One Session of Botulinum Toxin Type A in Patients With Jaw Myalgia: A Randomised Double\u2010Blind Controlled Multicentre Pilot Study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7055-2900","authenticated-orcid":false,"given":"Ava","family":"Minston","sequence":"first","affiliation":[{"name":"Department of Orofacial Pain and Jaw Function, Postgraduate Dental Education Center Public Dental Health Service  \u00d6rebro Sweden"},{"name":"Department of Orofacial Pain and Jaw Function Aqua Dental Specialist Clinic  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1530-7042","authenticated-orcid":false,"given":"Helene","family":"Abrahamsson","sequence":"additional","affiliation":[{"name":"The Maxillofacial Unit Halmstad Hospital  Halmstad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8972-6419","authenticated-orcid":false,"given":"Peter","family":"Abrahamsson","sequence":"additional","affiliation":[{"name":"The Maxillofacial Unit Halmstad Hospital  Halmstad Sweden"},{"name":"Department of Oral and Maxillofacial Surgery and Oral Medicine Malm\u00f6 University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6376-5436","authenticated-orcid":false,"given":"Erik","family":"Lindfors","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain and Jaw Function Public Dental Health Service  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1771-4635","authenticated-orcid":false,"given":"Eva","family":"Nohlert","sequence":"additional","affiliation":[{"name":"Region Vastmanland\u2014Uppsala University, Centre for Clinical Research V\u00e4stmanland Hospital  V\u00e4ster\u00e5s Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5764-1769","authenticated-orcid":false,"given":"Daniel","family":"Ovesson","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain and Jaw Function Karlstad Hospital  Karlstad Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2183-7497","authenticated-orcid":false,"given":"Negin","family":"Yekkalam","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain and Jaw Function V\u00e4stmanland County Hospital  V\u00e4ster\u00e5s Sweden"},{"name":"Department of Orofacial Pain and Jaw Function Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-5173","authenticated-orcid":false,"given":"G\u00f6ran","family":"Isacsson","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain and Jaw Function V\u00e4stmanland County Hospital  V\u00e4ster\u00e5s Sweden"},{"name":"Faculty of Medicine and Health University Health Care Research Center  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080030401"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.11607\/jop.1151"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.755"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90066-8"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.04.021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1981.sp013838"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2018.04.004"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004315.pub3"},{"issue":"6","key":"e_1_2_10_10_1","article-title":"Botulinum Toxins for the Prevention of Migraine in Adults","volume":"6","author":"Herd C. 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