{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:01:18Z","timestamp":1745985678273,"version":"3.40.4"},"reference-count":120,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,29]],"date-time":"2024-12-29T00:00:00Z","timestamp":1735430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202401166ZYTS"],"award-info":[{"award-number":["YDZJ202401166ZYTS"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies have linked sleep quality to temporomandibular joint disorders (TMD), suggesting a role for snoring in this association. However, the directionality of this relationship remains a subject of debate. This investigation aimed to elucidate the connections between snoring and TMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This research employed a two\u2010sample Mendelian randomization (MR) approach, leveraging publicly available large\u2010scale genome\u2010wide association study (GWAS) data on snoring and TMD. We utilised a suite of analytical methods, including the inverse variance weighted (IVW) method, maximum likelihood estimation, adjusted profile score, weighted median, MR\u2013Egger regression, and a series of sensitivity analyses, to rigorously assess the existence of relationships.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our findings indicate that a greater genetic predisposition to snoring is significantly associated with a reduced risk of TMD (IVW method; odds ratio [OR]\u2009=\u20090.156, 95% confidence interval [CI]\u2009=\u20090.028\u20130.843, <jats:italic>p<\/jats:italic>\u2009=\u20090.0309). Conversely, the analysis did not support a potential influence of TMD on snoring susceptibility (IVW method; 95% CI\u2009=\u20090.990 to 1.002, <jats:italic>p<\/jats:italic>\u2009=\u20090.1926). Additionally, our sensitivity analyses did not reveal any significant pleiotropy that could bias these findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This MR study provides limited but novel genetic evidence supporting a potential causal link between snoring and a decreased risk of developing TMD. On the other hand, it does not substantiate an effect of TMD on the likelihood of snoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.13916","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T06:42:02Z","timestamp":1735540922000},"page":"678-692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Snoring as a Possible Protective Factor for Temporomandibular Joint Disorders"],"prefix":"10.1111","volume":"52","author":[{"given":"Yi","family":"Wu","sequence":"first","affiliation":[{"name":"The First Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University  Changchun Jilin Province China"},{"name":"Department of Social Medicine and Health Management School of Public Health, Jilin University, Changchun  Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6740-0606","authenticated-orcid":false,"given":"Zhijun","family":"Bi","sequence":"additional","affiliation":[{"name":"Hunan University of Medicine  Huaihua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jintian","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Song","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyu","family":"Liao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Hospital of Chinese Medicine\u2010Zhuhai Hospital  Zhuhai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Jin","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8002-9556","authenticated-orcid":false,"given":"Zhiguo","family":"Bi","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Han","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Hospital of Jilin University  Changchun Jilin Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00012209"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.6.2209"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480152583700"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.01.017"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0847"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsw052"},{"key":"e_1_2_12_8_1","first-page":"1492","article-title":"Heavy Snoring as a Cause of Carotid Artery Atherosclerosis","volume":"31","author":"Lee S. 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