{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:50:04Z","timestamp":1773204604987,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hominis placenta (HP) exhibits anti\u2010inflammatory, antiviral and nerve growth\u2010promoting properties; however, there are limited studies about HP therapy in the treatment of temporomandibular disorder (TMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the cost\u2010effectiveness of HP therapy with that of physical therapy (PT) in patients with TMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cost\u2010effectiveness analysis was conducted alongside a 26\u2010week multicentre pragmatic randomised controlled trial (RCT). Eighty\u2010two patients with chronic TMD were randomly assigned to the HP and PT groups at a ratio of 1:1. Patients with a visual analogue scale (VAS) score of \u2265\u200940\u2009mm for temporomandibular joint pain and persistent pain for \u2265\u20093\u2009months were included. The primary economic endpoint was the incremental cost\u2010effectiveness ratio, which analysed the cost per quality\u2010adjusted life years (QALYs) gained in the HP group. QALYs were calculated using EuroQol\u20105D (EQ\u20105D) and Short\u2010Form 6D (SF\u20106D). The primary and secondary analyses were conducted from societal and healthcare perspectives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HP therapy was the dominant treatment option from a societal perspective owing to its higher QALY and lower cost compared with those of PT. Differences in QALYs calculated using EQ\u20105D and SF\u20106D between the two groups were 0.015 and 0.034, respectively, while those in cost from societal perspectives and healthcare perspectives were \u22123764 and 113 USD, respectively. Analysis from a healthcare perspective indicated that the incremental cost\u2010effectiveness ratio calculated using the EQ\u20105D and SF\u20106D was 7786 and 3338 USD, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HP therapy is a more cost\u2010effective therapeutic option than PT for patients with chronic TMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT04087005; Clinical Research Information Service KCT0004437\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13932","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T04:26:16Z","timestamp":1738556776000},"page":"807-816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cost\u2010Effectiveness of Hominis Placenta Therapy for Chronic Temporomandibular Disorder: An Economic Evaluation Alongside a Pragmatic Randomised Controlled Trial"],"prefix":"10.1111","volume":"52","author":[{"given":"Doori","family":"Kim","sequence":"first","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010San","family":"Kim","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koh\u2010Woon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Korean Rehabilitation Medicine, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Heung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Korean Rehabilitation Medicine, College of Korean Medicine Kyung Hee University  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1532-0942","authenticated-orcid":false,"given":"Yoon Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5020-6723","authenticated-orcid":false,"given":"In\u2010Hyuk","family":"Ha","sequence":"additional","affiliation":[{"name":"Jaseng Spine and Joint Research Institute Jaseng Medical Foundation  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12380"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2011.04.021"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107BOR-2015.vol29.0075"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-8-46"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-35552009005000028"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2427\/5790"},{"issue":"1","key":"e_1_2_10_8_1","first-page":"3","article-title":"Quality of Life in Patients With Temporomandibular Disorders. 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