{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:08Z","timestamp":1772160728323,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Recent studies have shown that capsaicin improves the pharyngeal swallowing reflex. However, the mechanism by which capsaicin alters mastication and oesophageal function remains unclear. This study aimed to investigate the effects of capsaicin on masticatory and oesophageal function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Participants were 12 healthy individuals (7 men, 5 women: aged 31.5\u2009\u00b1\u20093.0\u2009years). The participants ingested five rice cakes without capsaicin and then five rice cakes containing capsaicin. Total mastication frequency, total mastication time, and mastication rate were measured. Pharyngeal and upper oesophageal sphincter (UES) parameters were evaluated using high\u2010resolution manometry (HRM). The masticatory and HRM parameters were compared between the ingestion of capsaicin\u2010containing and non\u2010capsaicin containing rice cakes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The total mastication frequency and total mastication time(s) for capsaicin ingestion were significantly smaller (20.3\u2009\u00b1\u20099.4 vs. 22.4\u2009\u00b1\u20097.4;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and shorter (14.2\u2009\u00b1\u20097.0 vs. 15.4\u2009\u00b1\u20095.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038), respectively, than those for non\u2010capsaicin ingestion. Comparison of the HRM parameters revealed significantly higher hypopharyngeal contractile integral (mmHg\u2010s\u2010cm) (56.6\u2009\u00b1\u200940.7 vs. 49.7\u2009\u00b1\u200943.6;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016) and proximal oesophageal contractile integral (mmHg\u2010s\u2010cm) (492.3\u2009\u00b1\u2009292.64 vs. 381.2\u2009\u00b1\u2009266;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), significantly shorter UES basal pressure (mmHg) (93.6\u2009\u00b1\u200937.8 vs. 114.5\u2009\u00b1\u200943.4;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and significantly longer UES relaxation time (ms) (486.7\u2009\u00b1\u200990.7 vs. 431.2\u2009\u00b1\u200982.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) for capsaicin ingestion than for non\u2010capsaicin ingestion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Decreased mastication frequency and time, increased hypopharyngeal and proximal oesophageal contractile integral, and prolonged UES opening time with capsaicin ingestion suggests that capsaicin improves oral, pharyngeal and oesophageal phases of swallowing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13935","type":"journal-article","created":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T01:48:31Z","timestamp":1737769711000},"page":"825-832","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Capsaicin on Masticatory and Swallowing Function"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-0308","authenticated-orcid":false,"given":"Hiroshige","family":"Taniguchi","sequence":"first","affiliation":[{"name":"Division of Oral Pathogenesis and Disease Control, Department of Dysphagia Rehabilitation Asahi University School of Dentistry  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Hirumuta","sequence":"additional","affiliation":[{"name":"Division of Oral Pathogenesis and Disease Control, Department of Dysphagia Rehabilitation Asahi University School of Dentistry  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Division of Oral Pathogenesis and Disease Control, Department of Dysphagia Rehabilitation Asahi University School of Dentistry  Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Graduate School of Medicine Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0544-325X","authenticated-orcid":false,"given":"Yoichiro","family":"Aoyagi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Graduate School of Medicine Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.07.001"},{"issue":"4","key":"e_1_2_12_3_1","first-page":"440","article-title":"Age\u2010Related Changes in Swallowing","volume":"86","author":"Muhle P.","year":"2015","journal-title":"Physiology and Pathophysiology. 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