{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:18:06Z","timestamp":1789521486831,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The efficacy of conservative interventions targeting temporomandibular disorders (TMDs) in patients diagnosed with headaches has not been systematically reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To appraise the efficacy of conservative interventions targeting TMDs for adults with primary or secondary headaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Bibliographic searches were conducted up to September 2024 for randomised controlled trials in five databases: CINAHL, Cochrane CENTRAL, Embase, PEDro and PubMed. Outcomes collected were frequency, intensity and duration of headache episodes, and disability. Version 2 of the Cochrane Risk\u2010of\u2010Bias Tool and the GRADE approach were used for assessing the methodological quality and grading evidence. Results from trials with similar interventions and with similar outcome measures were pooled into separate meta\u2010analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five trials were included. Low\u2010certainty evidence suggests that the occlusal stabilisation appliance did not reduce headache frequency (SMD episode\/week: \u22121.57; 95% CI: \u22122.86 to \u22120.28; 3 RCTs;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009145) and intensity (SMD VAS: \u22120.24 points out of 10; 95% CI: \u22120.67 to 0.20; 2 RCTs;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200985) compared to non\u2010specific appliance therapy or no treatment at 1\u20133\u2009months post\u2010intervention. At 4\u20139\u2009months post\u2010intervention, low\u2010certainty evidence indicates that the occlusal stabilisation appliance therapy reduced headache frequency (SMD episode\/week: 1.21; 95% CI: 0.06 to 2.36; 3 RCTs;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009145), but not headache intensity (SMD VAS: \u22120.51 point out of 10; 95% CI: \u22121.01 to \u22120.02; 2 RCTs;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200985). Very low\u2010certainty evidence suggests that overall physiotherapy interventions reduced headache intensity compared to non\u2010specific exercises at 1\u20133\u2009months post\u2010intervention (SMD NPRS: 4.44 points out of 10; 95% CI: \u22120.46 to 9.34; 2 RCTs;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200967) and at 4\u20139\u2009months post\u2010intervention (SMD NPRS: 3.92 points out of 10; 95% CI: 0.75 to 7.09; 2 RCTs;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200967).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our results suggest that clinicians may consider combining orofacial stabilisation appliance therapy and physiotherapy interventions without certainty of their effects for the criteria assessed. The heterogeneity of the interventions assessed and the populations studied means that caution must be exercised when interpreting the results obtained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>#CRD42023389507<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.13994","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T23:54:49Z","timestamp":1746143689000},"page":"937-948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of Conservative Interventions Targeting Temporomandibular Disorders for Adults With Headache Disorders: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3794-2195","authenticated-orcid":false,"given":"Anthony","family":"Demont","sequence":"first","affiliation":[{"name":"INSERM UMR\u2010S 1153 Centre de Recherche \u00c9pid\u00e9miologique et Statistique Sorbonne Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Benaissa","sequence":"additional","affiliation":[{"name":"Physiotherapy Clinic  Marcq\u2010en\u2010Baroeul France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5043-8946","authenticated-orcid":false,"given":"Laurent","family":"Pitance","sequence":"additional","affiliation":[{"name":"Institute of Experimental and Clinical Research, Health Sciences Division, Neuro\u2010Musculo\u2010Skeletal\u2010Lab (NMSK) UCLouvain  Brussels Belgium"},{"name":"Oral and Maxillofacial Department Cliniques Universitaires Saint\u2010Luc  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010022\u201001402\u20102"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3203027"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b389c2"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468\u20102982.2007.01325.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/25158163221097352"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2019.04.003"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416686302"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12515"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.11607\/jop.1151"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msksp.2020.102277"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"},{"issue":"6","key":"e_1_2_12_16_1","first-page":"2","article-title":"GRADE: Assessing the Quality of Evidence for Diagnostic Recommendations","volume":"149","author":"Sch\u00fcnemann H. 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