{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:45:01Z","timestamp":1790873101262,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temporomandibular joint osteoarthritis (TMJ\u2010OA) presents a significant clinical challenge, marked by limited therapeutic options and variable patient responses. While regenerative therapies show promising results, conventional clinical trial methodologies often fail to demonstrate a significant clinical difference, largely due to response variabilities, which is critical in complex conditions like TMJ\u2010OA. As such, methodologies traditionally used in clinical trials for regenerative therapies targeting TMJ\u2010OA may need to be restructured to better identify and accommodate the distinctive profiles of responders and non\u2010responders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This paper proposes a revised clinical trial framework that focuses on differentiating responders from non\u2010responders within treatment groups, rather than relying solely on traditional control groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Analysing non\u2010responders provides valuable insights for therapeutic individualisation and optimises patient selection, as understanding predictive factors can lead to improved outcomes. We present recommendations that integrate imaging diagnostics, chronic pain characteristics, and psychosocial assessments, offering a novel approach to enhance efficacy of TMJ\u2010OA treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This work advocates for a re\u2010evaluation of standard clinical trial designs to support more personalised and effective strategies for the management of TMJ\u2010OA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.14012","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T05:30:15Z","timestamp":1747632615000},"page":"1674-1681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Redefining Clinical Trials on Regenerative Therapies to Target Responsiveness in Temporomandibular Joint Osteoarthritis Treatment"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-0981","authenticated-orcid":false,"given":"Ricardo de Souza","family":"Tesch","sequence":"first","affiliation":[{"name":"Petr\u00f3polis Medical School\/UNIFASE\/Regenerative Medicine Laboratory  Petr\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana Bizon Vieira","family":"Carias","sequence":"additional","affiliation":[{"name":"Petr\u00f3polis Medical School\/UNIFASE\/Regenerative Medicine Laboratory  Petr\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thayanne Brasil Barbosa","family":"Calcia","sequence":"additional","affiliation":[{"name":"Petr\u00f3polis Medical School\/UNIFASE\/Clinical Research Center  Petr\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila Grion de Miranda","family":"Borchio","sequence":"additional","affiliation":[{"name":"Petr\u00f3polis Medical School\/UNIFASE\/Regenerative Medicine Laboratory  Petr\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Rieko","family":"Takamori","sequence":"additional","affiliation":[{"name":"Petr\u00f3polis Medical School\/UNIFASE\/Regenerative Medicine Laboratory  Petr\u00f3polis Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12132"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5624\/isd.2020.50.3.245"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202207050"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.2018.1516183"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.18\u20100074"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.M.00261"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40744\u2010023\u201000573\u2010x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010018\u20101538\u20107"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00264\u2010017\u20103731\u20108"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.08.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/2177-6709.29.4.e24spe4"},{"issue":"4","key":"e_1_2_9_13_1","first-page":"333","article-title":"Prediction of TMJ Arthralgia According to Clinical Diagnosis and MRI Findings","volume":"19","author":"Ohlmann B.","year":"2006","journal-title":"International Journal of Prosthodontics"},{"issue":"3","key":"e_1_2_9_14_1","first-page":"239","article-title":"Association Between Temporomandibular Joint Symptoms, Signs, and Clinical Diagnosis Using the RDC\/TMD and Radiographic Findings in Temporomandibular Joint Tomograms","volume":"22","author":"Wiese M.","year":"2008","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002153"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1140"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516653743"},{"issue":"8","key":"e_1_2_9_18_1","first-page":"1785","article-title":"Determinants of Pain Severity in Knee Osteoarthritis: Effect of Demographic and Psychosocial Variables Using 3 Pain Measures","volume":"26","author":"Creamer P.","year":"1999","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2018.11.025"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2021.01.038"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szae026"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2022.08.001"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201060404\u2010z"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000784"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.02.016"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2022.07.012"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.781021"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3525"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.632717"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13545"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102419893823"},{"issue":"3","key":"e_1_2_9_32_1","first-page":"208","article-title":"Occurrence of Clinical Signs of Temporomandibular Disorders in Adult Finns","volume":"20","author":"Rutkiewicz T.","year":"2006","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.18\u20100053"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP087712"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-019-1345-2"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.14012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T03:48:14Z","timestamp":1760327294000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.14012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,19]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/joor.14012"],"URL":"https:\/\/doi.org\/10.1111\/joor.14012","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOOR.14012\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14012\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14012\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14012\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14012\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14012\/v1\/review1","asserted-by":"object"}]},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,19]]},"assertion":[{"value":"2023-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}