{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:24:45Z","timestamp":1785803085232,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Obstructive sleep apnea hypopnea syndrome (OSAHS) is a prevalent sleep\u2010breathing disorder affecting both adults and children. Although previous studies have suggested a potential association between OSAHS and oxidative stress biomarkers, particularly advanced oxidation protein products (AOPP), their conclusive relationship remains unclear. This systematic review and meta\u2010analysis aims to quantitatively synthesise existing evidence on the association between AOPP levels and OSAHS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We comprehensively searched PubMed, Wiley Online Library, Cochrane Library, CBM, and CNKI databases up to October 2023. Two independent researchers screened studies investigating AOPP\u2013OSAHS correlations, followed by data extraction and quality assessment. Statistical analyses were performed using Stata, with standardised mean differences (SMDs) calculated for pooled estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies comprising 608 patients and 770 controls were included. The meta\u2010analysis demonstrated significantly elevated AOPP concentrations in OSAHS patients compared to controls (SMD\u2009=\u20091.66\u2009, 95% CI\u2009=\u20091.02\u20132.29; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200996%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Meta\u2010regression identified significant associations between effect sizes and publication year (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.32, <jats:italic>p<\/jats:italic>\u2009=\u20090.016) as well as BMI (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.25, <jats:italic>p<\/jats:italic>\u2009=\u20090.028), independent of geographic region, sample type, or analytical methods. Secondary analyses of oxidative stress markers revealed consistent elevations in SOD and MDA levels among OSAHS patients, whereas GSH showed no significant difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The meta\u2010analysis confirmed a substantial increase in AOPP concentration in OSAHS patients compared to the control group, suggesting that the protein oxidation marker AOPP plays a role in the development of OSAHS and offering valuable insights for future clinical research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/joor.14013","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:09:29Z","timestamp":1747267769000},"page":"1591-1600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Advanced Oxidation Protein Products in Obstructive Sleep Apnea Hypopnea Syndrome\u2014A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1305-7551","authenticated-orcid":false,"given":"Shen\u2010sui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Stomatological Hospital of Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu\u2010dong","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Stomatological Hospital of Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u2010kun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Stomatological Hospital of Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010zhou","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Cancer Surgery, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Hospital of Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenglong","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Stomatological Hospital of Guizhou Medical University  Guiyang Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213\u20102600(19)30198\u20105"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.09.002"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1816152"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105369"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.08.010405"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920\u2010020\u201000755\u20104"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12050738"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/22.5.662"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010021\u201005765\u20103"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006904"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6006127"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2011.10.030"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8215082"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137560"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2004.11.001"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2013.6.2.68"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.09.024"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000002743"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392\u2010100X\u2010895"},{"issue":"2","key":"e_1_2_12_22_1","first-page":"159","article-title":"Advanced Oxidation Protein Products in Obstructive Sleep Apnea","volume":"109","author":"Sonka K.","year":"2008","journal-title":"Prague Medical Report"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7476"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000443527"},{"key":"e_1_2_12_25_1","first-page":"166","article-title":"Advanced Oxidation Protein Products. Part I. Mechanism of the Formation, Characteristics and Property","volume":"28","author":"Piwowar A.","year":"2010","journal-title":"Polski Merkuriusz Lekarski"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.38"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000100"},{"key":"e_1_2_12_28_1","unstructured":"Institute J. The Joanna Briggs Institute \u201cCritical Appraisal Tools for Use in JBI Systematic Reviews Checklist for Analytical Clinical Trial Studies \u201d2017 accessed November 27 2022."},{"key":"e_1_2_12_29_1","first-page":"15","article-title":"Assessing the Influence of a Single Study in the Meta\u2010Analysis Estimate","volume":"47","author":"Tobias A.","year":"1999","journal-title":"Stata Technical Bulletin"},{"issue":"2","key":"e_1_2_12_30_1","first-page":"209","article-title":"The Correlation Between Cognitive Impairment in Patients With Obstructive Sleep Apnea Syndrome (OSAHS) and Serum MCP\u20101, HSP70, and AOPP Levels","volume":"27","author":"Shen X. G.","year":"2020","journal-title":"Stroke and Nervous Diseases"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.80343"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12338"},{"issue":"30","key":"e_1_2_12_33_1","first-page":"3794","article-title":"Change of Serumal Advanced Oxidation Protein Products in Patients With Obstructive Sleep Apnea Hypopnea Syndrome","volume":"20","author":"Liu W.","year":"2011","journal-title":"Modern Journal of Integrated Traditional Chinese and Western Medicine"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12338"},{"issue":"21","key":"e_1_2_12_35_1","first-page":"1636","article-title":"The Relationship of Patients With Obstructive Sleep Apnea Hypopnea Syndrome Whose Serum Advanced Oxidation Protein Levels and Cognitive Function","volume":"34","author":"Xue J. S.","year":"2014","journal-title":"International Journal of Respiratory Medicine"},{"issue":"4","key":"e_1_2_12_36_1","first-page":"274","article-title":"Correlation Between the Serum Level of Advanced Oxidation Protein Products and the Cognitive Function in Patients With Obstructive Sleep Apnea Hypopnea Syndrome","volume":"36","author":"Yang X. H.","year":"2013","journal-title":"Chinese Journal of Tuberculosis and Respiratory Diseases"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9681595"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.07.003"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201056601\u2010w"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845\u2010020\u201002225\u20103"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.186"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071053"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2005.009"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00352\u20102021"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325\u2010012\u20100703\u20105"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192013219"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010021\u201007064\u20101"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2014.09.024"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.14013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T03:48:17Z","timestamp":1760327297000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.14013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,14]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/joor.14013"],"URL":"https:\/\/doi.org\/10.1111\/joor.14013","archive":["Portico"],"relation":{},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,14]]},"assertion":[{"value":"2024-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}