{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:11:27Z","timestamp":1792012287827,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence supports the use of exercise for patients with temporomandibular disorders (TMDs). However, previous studies have mainly focused on combined treatment strategies or undefined exercise modalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review aims to evaluate the effectiveness of Resistance Training (RT) as a standalone treatment for managing pain and improving neuromuscular performance in individuals with TMDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review followed a pre\u2010established and published protocol, which was registered with PROSPERO (CRD42023476269). The literature search was conducted from March 1st 2024 to March 31st 2024 via the following electronic databases: MEDLINE (OVID interface), EMBASE (OVID interface), SCOPUS, Web of Science, PubMed, and Cochrane Central Register of Controlled Trials (CENTRAL). Randomised controlled trials or nonrandomised studies of interventions were included when they compared the effect of RT targeting masticatory muscles on pain, neuromuscular performance, and maximum mouth opening in patients with TMDs versus other treatment modalities. Two independent reviewers screened articles for inclusion, extracted data, assessed the risk of bias using the revised Cochrane risk of bias tool for randomised trials and evaluated the overall quality of evidence using the Grading of Recommendations, Assessment, Development and Evaluations approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From an initial 2177 articles, only three met the inclusion criteria and involved 108 participants. All the included studies demonstrated a decrease in pain intensity and an improvement in neuromuscular performance following RT, even if the superiority of RT over other interventions remains uncertain. However, the combination of moderate risk of bias, significant heterogeneity and small sample sizes resulted in a very low quality of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinicians managing patients with TMDs should consider RT as an effective, conservative option in conjunction with other treatment modalities. Future methodologically robust studies with large sample sizes and clearly defined exercise protocols are needed to investigate the role of RT for reducing TMD\u2010related pain by increasing load tolerance and addressing potential bruxism\u2010related muscle overload.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.14021","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:53:31Z","timestamp":1748220811000},"page":"1505-1517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of Resistance Training of Masticatory Muscles for Patients With Temporomandibular Disorders: A Systematic Review"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1683-7203","authenticated-orcid":false,"given":"Giacomo","family":"Asquini","sequence":"first","affiliation":[{"name":"Centre of Precision Rehabilitation for Spinal Pain, School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences University of Birmingham  Birmingham UK"},{"name":"Department of Human Neurosciences University of Roma \u201cLa Sapienza\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Pisacane","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences University of Roma \u201cLa Sapienza\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Maselli","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences University of Roma \u201cLa Sapienza\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firas","family":"Mourad","sequence":"additional","affiliation":[{"name":"Department of Health LUNEX University of Applied Sciences  Differdange Luxembourg"},{"name":"Luxembourg Health &amp; Sport Sciences Research Institute A.S.B.l.  Differdange Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bizzarri","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences University of Roma \u201cLa Sapienza\u201d  Rome Italy"},{"name":"Experimental Anatomy Research Group (EXAN) Vrije Universiteit Brussel (VUB)  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Balli","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences University of Roma \u201cLa Sapienza\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Bagnoli","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences University of Roma \u201cLa Sapienza\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Manzari","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences University of Roma \u201cLa Sapienza\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pernici","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences University of Roma \u201cLa Sapienza\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Giusti","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences University of Roma \u201cLa Sapienza\u201d  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1689-6190","authenticated-orcid":false,"given":"Deborah","family":"Falla","sequence":"additional","affiliation":[{"name":"Centre of Precision Rehabilitation for Spinal Pain, School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences University of Birmingham  Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2022.06.001"},{"key":"e_1_2_9_3_1","volume-title":"Orofacial Pain Guidelines for Assessment, Diagnosis, and Management","author":"De Leeuw R.","year":"2013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ors.12473"},{"issue":"6","key":"e_1_2_9_5_1","first-page":"378","article-title":"Diagnosis and Treatment of Temporomandibular Disorders","volume":"91","author":"Gauer R. L.","year":"2015","journal-title":"American Family Physician"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2013.09.010"},{"issue":"3","key":"e_1_2_9_7_1","first-page":"190","article-title":"Temporomandibular Joint and Muscle Disorder\u2010Type Pain and Comorbid Pains in a National US Sample","volume":"25","author":"Plesh O.","year":"2011","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245999"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2018.07.007"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010016\u20101912\u20102"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12497"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2016.08.022"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2013.04.006"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010015\u20100586\u20105"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010021\u201001623\u20107"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.2359"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13299"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12770"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211050326"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004250.pub5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000335.pub2"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215515570379"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178621"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2010.079376"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914\u2010022\u201000739\u20106"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3041"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2012.734411"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12662"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13462"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13411"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20140548"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269215516672275"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm\u201021\u2010451"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/02692155221133523"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnaa021"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7647"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102023\u2010083133"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.11607\/jop.1151"},{"issue":"4","key":"e_1_2_9_39_1","first-page":"301","article-title":"Research Diagnostic Criteria for Temporomandibular Disorders: Review, Criteria, Examinations and Specifications, Critique","volume":"6","author":"Dworkin S. F.","year":"1992","journal-title":"Journal of Craniomandibular Disorders"},{"key":"e_1_2_9_40_1","unstructured":"J. P. T.HigginsandS.Green eds. \u201cCochrane Handbook for Systematic Reviews of Interventions Version 5.1.0.\u201d(2011) [Updated March 2011]. The Cochrane Collaboration www.cochrane\u2010handbook.org."},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.09.012"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.BRS.0000065484.95996.AF"},{"key":"e_1_2_9_43_1","unstructured":"J. A. C.Sterne J.Savovi\u0107 M. J.Page et\u00a0al. \u201cRevised Cochrane Risk\u2010Of\u2010Bias Tool for Randomized Trials (RoB 2). Version 2.0.\u201d(2019) The Cochrane Collaboration https:\/\/www.riskofbias.info\/welcome\/rob\u20102\u20100\u2010tool."},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010016\u20100259\u20108"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6890"},{"key":"e_1_2_9_46_1","unstructured":"H.Sch\u00fcnemann J.Bro\u017cek G.Guyatt andA.Oxman \u201cGRADE Hand\u2010Book for Grading Quality of Evidence and Strength of Recommendations.\u201d(2013) Updated October 2013: the GRADE Working Group https:\/\/www.guidelinedevelopment.org\/handbook."},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12823"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1179\/crn.2006.030"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/86.7.955"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000247"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00164.2004"},{"issue":"3","key":"e_1_2_9_52_1","first-page":"300","article-title":"How Do Tendons Adapt? Going Beyond Tissue Responses to Understand Positive Adaptation and Pathology Development: A Narrative Review","volume":"19","author":"Docking S. I.","year":"2019","journal-title":"Journal of Musculoskeletal & Neuronal Interactions"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1179\/crn.2013.030"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12020501"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.14021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T05:14:14Z","timestamp":1756962854000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.14021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,25]]},"references-count":53,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1111\/joor.14021"],"URL":"https:\/\/doi.org\/10.1111\/joor.14021","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOOR.14021\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14021\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14021\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14021\/v2\/decision1","asserted-by":"object"}]},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,25]]},"assertion":[{"value":"2024-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}