{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:40:05Z","timestamp":1789908005811,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016958","name":"Office of Research Infrastructure Programs","doi-asserted-by":"publisher","award":["P51OD010425"],"award-info":[{"award-number":["P51OD010425"]}],"id":[{"id":"10.13039\/100016958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016958","name":"Office of Research Infrastructure Programs","doi-asserted-by":"publisher","award":["U42OD011123"],"award-info":[{"award-number":["U42OD011123"]}],"id":[{"id":"10.13039\/100016958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several age\u2010related oral health problems have been associated with neurodegenerative diseases such as Alzheimer's Disease (AD) and Parkinson's Disease (PD). However, the distinction between oromotor dysfunctions in healthy aging and pathological aging remains unclear. This is partly because changes in the cortical and biomechanical (\u201cneuromechanical\u201d) control of oromotor behaviour in healthy aging are poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of the study was to evaluate age\u2010related changes in tongue and jaw kinematics during natural feeding behaviour in non\u2010human primates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We captured three\u2010dimensional tongue and jaw movements in young and aged rhesus macaques (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Macaca mulatta<\/jats:italic>\n                      <\/jats:styled-content>\n                      ) using high\u2010resolution biplanar videoradiography combined with X\u2010ray Reconstruction of Moving Morphology (XROMM). This approach allowed precise tracking of tongue and jaw kinematics during natural feeding behaviour. Tongue stereotypy and velocity were quantitatively assessed, along with the temporal coordination between tongue and jaw movements. Feeding performance was measured using frequency and duration of food manipulation, chewing, and swallowing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Older subjects exhibited reduced stereotypy in tongue movements during chews and greater lags in tongue movements relative to jaw movements compared to younger subjects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings reveal age\u2010related changes in tongue and jaw kinematics, which may indicate impaired tongue\u2010jaw coordination. These results have important implications for the discovery of potential neuromechanical biomarkers for early diagnosis of AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.14035","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T07:36:35Z","timestamp":1747985795000},"page":"1746-1756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Healthy Aging on Tongue\u2010Jaw Kinematics During Feeding"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4523-9627","authenticated-orcid":false,"given":"Shreyas","family":"Punacha","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences, School of Dentistry University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences, School of Dentistry University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritzie I.","family":"Arce\u2010McShane","sequence":"additional","affiliation":[{"name":"Department of Oral Health Sciences, School of Dentistry University of Washington  Seattle Washington USA"},{"name":"Division of Neuroscience, Washington National Primate Research Center University of Washington  Seattle Washington USA"},{"name":"Graduate Program in Neuroscience University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/CHEST.124.1.328"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1532\u20105415.2012.04064.X"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUCLI.2015.12.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JDSR.2014.09.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00009582"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3913(98)70134-9"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2008.05.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/FNSYS.2023.1213279"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHYS.2020.00034"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1990.tb00954.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(01)00023-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3913(97)70228-2"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-4603.2002.tb01349.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.4.506"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CLINPH.2016.05.363"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2011.11.060"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROIMAGE.2014.12.023"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUROBIOLAGING.2018.12.013"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.20900\/agmr20210011"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1079\/NRR200375"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2016.12.005"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/2022.05.10.491373"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1458\u201024.2024"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201038586\u20103"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.226720"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/JEZ.589"},{"issue":"23","key":"e_1_2_10_28_1","first-page":"3701","article-title":"Validation of XMALab Software for Marker\u2010Based XROMM","volume":"219","author":"Kn\u00f6rlein B. J.","year":"2016","journal-title":"Journal of Experimental Biology"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010018\u20100209\u2010y"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1242\/JEB.119438"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.239509"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(95)98812-D"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092\u20104388(2009\/08\u20100131)"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0079555"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002210050228"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1037\/0096\u20101523.22.5.1059"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/PHYSREV.1996.76.3.687"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1109\/JOE.2004.833102"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.05-10-02732.1985"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/GERONA\/50A.5.M257"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/03610738408258548"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010022\u201003027\u20102"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3300\u201007.2008"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/MUS.25605"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.NEUBIOREV.2009.10.005"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1044\/2022_JSLHR\u201022\u201000594"},{"key":"e_1_2_10_47_1","article-title":"Phase Relations Between the Tongue Body and the Jaw Across Rate Modifications in Younger and Older Speakers","author":"Thies T.","journal-title":"Speech Production and Speech Physiology"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.14035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T03:48:15Z","timestamp":1760327295000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.14035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":46,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/joor.14035"],"URL":"https:\/\/doi.org\/10.1111\/joor.14035","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOOR.14035\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14035\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14035\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14035\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14035\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14035\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14035\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.14035\/v3\/response1","asserted-by":"object"}]},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]},"assertion":[{"value":"2024-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}