{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T21:13:52Z","timestamp":1773177232345,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sensorimotor processing is critical to the ageing brain and geriatric health. Masticatory performance (MP) is key to the systemic health of older individuals. Neuroimaging research has revealed a potential link between brain functional connectivity (FC) and MP. Using the masticatory perturbation task (MPT), we investigated the FC associated with MP under different conditions of task demand and age groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010four older\u2010age (OA, \u2265\u200965\u2009years), 26 middle\u2010aged (MA, between 40 and 64\u2009years) and 42 younger\u2010age (YA, &lt;\u200940\u2009years) participants were recruited for assessment of the MPT, and structural and resting\u2010state (rs) functional magnetic resonance imaging (MRI). Analyses of seed\u2010based connectivity and FC networks were conducted to investigate the rs\u2010FC associated with MP in the baseline condition (without perturbation) and the perturbation condition (with perturbation) of MPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>(A) In the baseline condition, OA participants with better MP showed higher rs\u2010FC between the cerebellum and primary sensorimotor cortices. (B) In the perturbation condition, OA participants with better MP showed higher rs\u2010FC between the middle frontal gyrus and the primary somatosensory cortex, and MA participants with better MP showed higher rs\u2010FC between the supplementary motor area and the caudate nucleus. (C) The network analysis revealed that the pattern of rs\u2010FC related to MP differed between age groups and task conditions. In the perturbation condition, YA participants with better MP showed higher rs\u2010FC outside the sensorimotor network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings provide novel evidence demonstrating an interaction between age and task demand on rs\u2010FC associated with MP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.14036","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T07:35:24Z","timestamp":1747985724000},"page":"1757-1767","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interaction Between Age and Task Demand on Brain Connectivity Associated With Mastication"],"prefix":"10.1111","volume":"52","author":[{"given":"Chia\u2010Shu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Dentistry National Yang Ming Chiao Tung University  Taipei City Taiwan"},{"name":"Institute of Brain Science National Yang Ming Chiao Tung University  Taipei City Taiwan"},{"name":"Brain Research Center National Yang Ming Chiao Tung University  Taipei City Taiwan"},{"name":"Oral Medicine Innovation Center National Yang Ming Chiao Tung University  Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Chieh","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Dentistry National Yang Ming Chiao Tung University  Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03027-2"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13034"},{"issue":"10","key":"e_1_2_12_4_1","first-page":"4923","article-title":"Resting\u2010State Functional Connectivity Is an Age\u2010Dependent Predictor of Motor Learning Abilities","volume":"27","author":"Mary A.","year":"2017","journal-title":"Cerebral Cortex"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","unstructured":"A.Sansare T. 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