{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:00:44Z","timestamp":1787068844572,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temporomandibular disorders (TMDs) are multifactorial conditions with diverse clinical presentations, making standardised treatment approaches difficult to establish. Despite an increasing number of randomised controlled trials (RCTs) globally, methodological inconsistencies and research waste remain significant obstacles to evidence integration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study systematically analysed 103 TMDs\u2010related RCTs registered on\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      (2005\u20132025) to identify contributors to research waste and propose mitigation strategies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The analysis covered trial characteristics, publication status, adherence to CONSORT guidelines, and Cochrane risk\u2010of\u2010bias assessments. Statistical analyses included chi\u2010square or Fisher's exact tests and logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a clear upward trend in RCT registrations and subsequent publications. The majority focused on pain\u2010related TMDs (85.52%) and non\u2010invasive interventions (85.44%). However, 31.07% of pain\u2010related TMDs trials lacked clear subdiagnosis. Published trials and those without design flaws were more likely to include invasive interventions (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and open\u2010label designs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). Pharmacological and larger sample sizes, multi\u2010arm designs, and open\u2010label protocols were identified as potential contributors to research waste.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Future research should emphasise clinician training in TMDs subdiagnosis and adopt feasibility\u2010driven trial designs, including comprehensive assessments of recruitment capacity and intervention feasibility. Addressing these factors may optimise RCTs quality and reduce research waste.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70002","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T01:29:47Z","timestamp":1750210187000},"page":"1228-1242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Research Waste in Temporomandibular Disorders Among Registered Randomised Controlled Trials: A Meta\u2010Epidemiologic Study"],"prefix":"10.1111","volume":"52","author":[{"given":"Ruopeng","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan China"},{"name":"Department of Radiology, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"West China School of Medicine and West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"West China School of Medicine and West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-7021","authenticated-orcid":false,"given":"Ji Woon","family":"Park","sequence":"additional","affiliation":[{"name":"Dental Research Institute Seoul National University  Seoul Korea"},{"name":"Department of Oral Medicine and Oral Diagnosis, School of Dentistry Seoul National University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2175-0970","authenticated-orcid":false,"given":"Xin","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; 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