{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:57:24Z","timestamp":1783475844852,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temporomandibular disorder (TMD) is a multifactorial condition characterised by pain and functional impairment in the orofacial region. Although psychosocial and psychophysical factors significantly influence chronic pain, their combined impact on functional disability remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the influence of clinical, psychosocial and psychophysical variables on functional disability related to chronic pain in muscular TMD, utilising principal component analysis (PCA) and logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study with 77 women with painful TMD assessed clinical parameters (pain intensity, frequency, comorbidities and duration), psychosocial characteristics (stress, anxiety, depression, sleep quality and pain catastrophising) and psychophysical assessments (pressure pain threshold, mechanical pain threshold and conditioned pain modulation). PCA identified principal components, which were analysed using logistic regression to evaluate their association with chronic pain grades through the Graded Chronic Pain Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five principal components were identified: psychosocial, clinical pain, duration and extent of pain, pain modulation and sensory. The clinical pain component significantly predicted functional disability across all chronic pain grades (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The psychosocial component was a strong predictor of higher disability levels, whereas the pain modulation component showed a protective effect at the highest disability grade.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Functional disability in TMD is influenced by a complex interplay of clinical, psychosocial and psychophysical factors. Among five components founded, clinical pain and psychosocial components emerged as the most significant predictors of functional disability, with pain modulation providing a protective role at higher disability levels. This study elucidates the intricate interplay between clinical, psychosocial and psychophysical factors contributing to functional disability in chronic TMD\u2010related pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70008","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T02:30:04Z","timestamp":1750991404000},"page":"2021-2030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interplay of Psychosocial, Clinical and Modulation Mechanisms in Chronic\n                    <scp>TMD<\/scp>\n                    \u2010Related Disability"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9143-7288","authenticated-orcid":false,"given":"Rafaela Stocker","family":"Salbego","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-4658","authenticated-orcid":false,"given":"Paulo C\u00e9sar Rodrigues","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontology, Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus","family":"Herreira\u2010Ferreira","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Amaral de Lima","family":"Netto","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany Karoline Barroso","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri Martins","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Piracicaba School of Dentistry University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-7678","authenticated-orcid":false,"given":"Leonardo Rigoldi","family":"Bonjardim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Bauru School of Dentistry University of S\u00e3o Paulo  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2010.08.007"},{"key":"e_1_2_10_3_1","volume-title":"Orofacial Pain: Guidelines for Assessment, Diagnosis, and Management","author":"De Leeuw R.","year":"2018"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2011.08.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708601119"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103959(92)90154\u20104"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90066-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32836336ad"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2016.01.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033\u20102909.133.4.581"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2021.779068"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pme.12230"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221\u2010014\u20103997\u20107"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516653743"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2011.654241"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.11607\/ofph.1319"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2022.09.017"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9020452"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.013"},{"key":"e_1_2_10_20_1","unstructured":"F. J.Pereira Jr. C.Maria Camparis andR.Tesch \u201cDiagnostic Criteria for Temporomandibular Disorders: Assessment Instruments (Brazilian Portuguese) Crit\u00e9rios de Diagn\u00f3stico Para Desordens Temporomandibulares: Protocolo Cl\u00ednico e Instrumentos de Avalia\u00e7\u00e3o Brazilian Portuguese Translation by Collaborators\u201d(2014) https:\/\/www.rdc\u2010tmdinternational.org."},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.11607\/jop.1151"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2018.06.001"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1287"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.04.020"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526\u20104637.2012.01492.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359105309346343"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034\u201089101995000500004"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S131479"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0034\u201070942006000500005"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1037\/1040\u20103590.7.4.524"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136404"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.02.003"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.06.029"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.10.001"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2010.02.004"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12745"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000325"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12692"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2015.06.001"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain\u20102017\u20100109"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.02.021"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.605"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001664"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10865\u2010012\u20109424\u20102"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000887"}],"container-title":["Journal of Oral Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.70008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/joor.70008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/joor.70008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:44:07Z","timestamp":1780029847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/joor.70008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":46,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/joor.70008"],"URL":"https:\/\/doi.org\/10.1111\/joor.70008","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JOOR.70008\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.70008\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.70008\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.70008\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.70008\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.70008\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JOOR.70008\/v1\/review1","asserted-by":"object"}]},"ISSN":["0305-182X","1365-2842"],"issn-type":[{"value":"0305-182X","type":"print"},{"value":"1365-2842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]},"assertion":[{"value":"2024-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}