{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:04:48Z","timestamp":1780031088131,"version":"3.53.1"},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Laryngeal penetration and aspiration are major global health concerns, especially in patients with dysphagia. Despite their serious impact, previous meta\u2010analyses evaluating their overall prevalence remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To estimate the prevalence of laryngeal penetration and aspiration in patients with oropharyngeal and oesophageal dysphagia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A comprehensive search of seven databases (Embase, Scopus, Web of Science, PubMed, CINAHL and ProQuest) was conducted without restriction by region, language, or publication date. A generalised linear mixed model and random\u2010effects model were used to calculate pooled prevalence estimates. Moderator analyses were performed to explore potential sources of heterogeneity. All statistical analyses were conducted using R software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 46 studies involving 5535 patients with dysphagia across 19 countries were included. The pooled prevalence of laryngeal penetration was 48.5%, highest among those with oropharyngeal dysphagia and in North America. Aspiration prevalence was 30.0%, highest in Europe. The prevalence of laryngeal penetration and aspiration was between 49.3% and 29.4%, respectively, in patients with oropharyngeal dysphagia and 31.5% and 12.6%, respectively, in those with oesophageal dysphagia. Significant moderators included hospital setting, male sex, oropharyngeal dysphagia, dysphagia aetiology, pharyngeal reflex delay, dysfunction of the vallecula and pyriform sinuses, impaired laryngeal closure, oral residue, oral feeding, laryngotracheal aspiration, silent aspiration and current smoking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Laryngeal penetration and aspiration are highly prevalent in dysphagia, particularly in oropharyngeal dysphagia. Early identification of risk factors and targeted interventions are critical to minimising complications and enhancing patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Understanding high prevalence and key moderators of laryngeal penetration and aspiration in dysphagia, especially oropharyngeal types, underscores the need for proactive screening and personalised management to prevent laryngeal penetration and aspiration\u2010related complications and improve quality of care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70021","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T02:15:04Z","timestamp":1753409704000},"page":"2131-2151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laryngeal Penetration and Aspiration Among Patients With Oropharyngeal and Oesophageal Dysphagia: A Meta\u2010Analysis and Moderator Analysis"],"prefix":"10.1111","volume":"52","author":[{"given":"Alfiani Rahmi","family":"Putri","sequence":"first","affiliation":[{"name":"School of Nursing College of Nursing, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Hao","family":"Chu","sequence":"additional","affiliation":[{"name":"School of Nutrition and Health Sciences, College of Nutrition Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidayat","family":"Arifin","sequence":"additional","affiliation":[{"name":"School of Nursing College of Nursing, Taipei Medical University  Taipei Taiwan"},{"name":"Department of Basic Nursing Faculty of Nursing, Universitas Airlangga  Surabaya Indonesia"},{"name":"Research Group in Medical\u2010Surgical Nursing Faculty of Nursing, Universitas Airlangga  Surabaya Indonesia"},{"name":"Department of Epidemiology and Public Health Medical Research Center of Indonesia  Surabaya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kondwani Joseph","family":"Banda","sequence":"additional","affiliation":[{"name":"School of Nursing College of Nursing, Taipei Medical University  Taipei Taiwan"},{"name":"Endoscopy Unit Department of Surgery, Kamuzu Central Hospital  Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Mei","family":"Sung","sequence":"additional","affiliation":[{"name":"School of Nursing National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010You","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Nursing College of Nursing, Taipei Medical University  Taipei Taiwan"},{"name":"Post\u2010Baccalaureate Program in Nursing, College of Nursing Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruey","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Nursing College of Nursing, Taipei Medical University  Taipei Taiwan"},{"name":"Post\u2010Baccalaureate Program in Nursing, College of Nursing Taipei Medical University  Taipei Taiwan"},{"name":"Department of Nursing Taipei Medical University\u2010Shuang Ho Hospital  New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pi\u2010Yu","family":"Su","sequence":"additional","affiliation":[{"name":"School of Nursing College of Nursing, Taipei Medical University  Taipei Taiwan"},{"name":"Department of Nursing, Wan Fang Hospital Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4882-3503","authenticated-orcid":false,"given":"Kuei\u2010Ru","family":"Chou","sequence":"additional","affiliation":[{"name":"School of Nursing College of Nursing, Taipei Medical University  Taipei Taiwan"},{"name":"Department of Nursing Taipei Medical University\u2010Shuang Ho Hospital  New Taipei Taiwan"},{"name":"Research Center in Nursing Clinical Practice Wan Fang Hospital Taipei Medical University  Taipei Taiwan"},{"name":"Psychiatric Research Center Taipei Medical University Hospital  Taipei Taiwan"},{"name":"Research Center for Neuroscience Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2021.05.013"},{"key":"e_1_2_9_3_1","unstructured":"TCD \u201cWhat is Dysphagia? 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