{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:36:48Z","timestamp":1792791408821,"version":"4.5.0"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005761","name":"Sahlgrenska Akademin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007212","name":"V\u00e4stra G\u00f6talandsregionen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007212","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Conventional treatment for reducing pain is not always successful in patients with chronic orofacial myalgia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to investigate the pain\u2010reducing efficacy of two botulinum toxin A injections in patients with chronic orofacial myalgia who had already received conservative treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The patients included were 18\u2009years or older and diagnosed with myalgia according to the Diagnostic Criteria for Temporomandibular Disorders. Their pain had persisted for more than six months in spite of previous conservative treatment. The design was a randomised, double\u2010blind, placebo\u2010controlled, multicenter, parallel group study. Participants received two injections of botulinum toxin A or saline at an interval of three months. Follow\u2010up visits were conducted at one, three, four, six and nine months after the first injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010two patients were enrolled and sixty\u2010nine completed the study. Between baseline and all follow\u2010up visits, there was a significant decrease in VAS pain intensity for both groups, but the difference between groups was not significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of botulinum toxin A in managing chronic orofacial myalgia did not offer any additional pain relief compared with saline at any of the follow\u2010up occasions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70032","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T10:10:26Z","timestamp":1754475026000},"page":"2291-2301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Two Botulinum Toxin A Injections in Patients With Chronic Orofacial Myalgia: A Randomised, Double\u2010Blind, Controlled Multicenter Trial With Nine\u2010Month Follow\u2010Up"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0134-810X","authenticated-orcid":false,"given":"Christine","family":"Lennartsson","sequence":"first","affiliation":[{"name":"Clinic of Orofacial Pain M\u00f6lndal, Public Dental Service, Region V\u00e4stra G\u00f6taland  Sweden"},{"name":"Department of Orofacial Pain Institute of Odontology, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9701-6249","authenticated-orcid":false,"given":"Ellie","family":"Saghafi","sequence":"additional","affiliation":[{"name":"Clinic of Orofacial Pain Gothenburg, Public Dental Service, Region V\u00e4stra G\u00f6taland  Sweden"},{"name":"Department of Oral and Maxillofacial Surgery Institute of Odontology, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7447-0580","authenticated-orcid":false,"given":"Behnosh \u00d6hrnell","family":"Malekzadeh","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Institute of Odontology, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Clinic of Oral and Maxillofacial Surgery Bor\u00e5s, Public Dental Service, Region V\u00e4stra G\u00f6taland  Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8539-7742","authenticated-orcid":false,"given":"Per","family":"Alstergren","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain and Jaw Function Faculty of Odontology, Malm\u00f6 University  Malm\u00f6 Sweden"},{"name":"Scandinavian Center for Orofacial Neurosciences  Malm\u00f6 Sweden"},{"name":"Specialized Pain Rehabilitation Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1238-5644","authenticated-orcid":false,"given":"Birgitta Johansson","family":"Cahlin","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain Institute of Odontology, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Clinic of Orofacial Pain Gothenburg, Public Dental Service, Region V\u00e4stra G\u00f6taland  Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080030401"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001872"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1990.0059"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1990.0043"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.01.012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(03)00074-5"},{"issue":"3","key":"e_1_2_10_8_1","first-page":"240","article-title":"Comparing TMD Diagnoses and Clinical Findings at Swedish and US TMD Centers Using Research Diagnostic Criteria for Temporomandibular Disorders","volume":"10","author":"List T.","year":"1996","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001384"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1533-2500.2004.04301.x"},{"issue":"2","key":"e_1_2_10_11_1","first-page":"93","article-title":"The Etiology of Temporomandibular Disorders: Implications for Treatment","volume":"15","author":"Greene C. 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