{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:52:08Z","timestamp":1772160728918,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n This study investigates the interaction between the motor endplate of the genioglossus and the hypoglossal nerve in an obstructive sleep apnea (OSA) model and explores the mechanism of mandibular advancement devices (MAD) in treating OSA.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n 18 male New Zealand white rabbits were randomly divided into three groups\u2014control,\n OSA<\/jats:styled-content>\n and\n MAD<\/jats:styled-content>\n (\n n<\/jats:italic>\n \u2009=\u20096 each).\n OSA<\/jats:styled-content>\n was induced in the\n OSA<\/jats:styled-content>\n and\n MAD<\/jats:styled-content>\n groups by injecting gel into the soft palate. The\n MAD<\/jats:styled-content>\n group received\n MAD<\/jats:styled-content>\n treatment. Cone\u2010beam computed tomography (\n CBCT<\/jats:styled-content>\n ) and polysomnography (\n PSG<\/jats:styled-content>\n ) confirmed\n MAD<\/jats:styled-content>\n efficacy. Rabbits underwent 2\u2009h of sleep induction daily for 8\u2009weeks. Electrophysiological signals of the genioglossus and hypoglossal nerve were recorded. Morphological assessments of nerve fibres and motor endplates used gold chloride, acetylcholine and haematoxylin\u2013Eosin (\n HE)<\/jats:styled-content>\n staining. Immunofluorescence and acetylcholinesterase (\n AChE<\/jats:styled-content>\n ) staining evaluated nerve conduction.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n OSA<\/jats:styled-content>\n symptoms were successfully induced and reversed by\n MAD<\/jats:styled-content>\n . Structural and functional impairments of the hypoglossal nerve and motor endplates in the\n OSA<\/jats:styled-content>\n group were alleviated by\n MAD<\/jats:styled-content>\n , improving nerve impulse conduction and muscle function.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n MAD<\/jats:styled-content>\n treatment mitigates\n OSA<\/jats:styled-content>\n \u2010induced damage to the hypoglossal nerve and genioglossus motor endplates, enhancing structure and function.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/joor.70060","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T06:49:36Z","timestamp":1759560576000},"page":"127-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mandibular Advancement Device Improves the Function of Hypoglossal Nerve in\n OSA<\/scp>\n Rabbits"],"prefix":"10.1111","volume":"53","author":[{"given":"Xing","family":"Qiao","sequence":"first","affiliation":[{"name":"Hebei Key Laboratory of Stomatology, Department of Orthodontics, School and Hospital of Stomatology, Hebei Clinical Research Center for Oral Diseases Hebei Medical University Shijiazhuang Hebei Province PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8237-1731","authenticated-orcid":false,"given":"Dechao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hebei Key Laboratory of Stomatology, Department of Orthodontics, School and Hospital of Stomatology, Hebei Clinical Research Center for Oral Diseases Hebei Medical University Shijiazhuang Hebei Province PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Hebei Medical University Shijiazhuang 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