{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T15:05:08Z","timestamp":1774019108428,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to determine the optimal timing and viscosity of thickened liquid intake for patients undergoing tongue and floor\u2010of\u2010mouth tumour resection with reconstruction, using VFSS to reduce nasogastric tube dependence, improve swallowing function, and the quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomised controlled trial was conducted at a dental specialty hospital from September 2023 to November 2024. Forty\u2010three patients who underwent free flap reconstruction for tongue and floor\u2010of\u2010mouth tumours were randomly divided into control (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) and intervention groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921). Both received swallowing training, but the intervention group followed a structured oral intake protocol with thickened liquids. After tracheostomy removal, patients received 5\u2009mL of medium\u2010viscosity liquid. If no aspiration occurred, VFSS was performed using 5\u2009mL each of medium\u2010, low\u2010 and high\u2010viscosity liquids. The liquid with the lowest PAS score was selected for oral intake. Nasogastric tubes were removed upon safe consumption of 200\u2009mL within 20\u2009min. Outcomes included tube duration, swallowing function, weight loss and quality of life.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      VFSS revealed increasing penetration risk with viscosity: 52.4% for low\u2010viscosity, 23.8% for medium\u2010viscosity and 19.0% for high\u2010viscosity liquids. Low\u2010viscosity liquids exhibited an aspiration rate of 14.3%, whereas no aspiration was observed with medium\u2010 or high\u2010viscosity liquids. The intervention group had shorter nasogastric tube duration (9.2 vs. 15.6\u2009days,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), better swallowing function, less weight loss and higher quality of life (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A structured thickened liquid diet protocol safely reduces nasogastric tube dependence, enhances swallowing function and quality of life postoperatively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70080","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T08:53:01Z","timestamp":1761382381000},"page":"357-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Timing of Thickened Liquid Intake After Tongue and Floor\u2010of\u2010Mouth Tumour Reconstruction: A Randomised Controlled Trial"],"prefix":"10.1111","volume":"53","author":[{"given":"Hong\u2010Yun","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology &amp; National Center of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology &amp; National Center of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Radiology Beijing Haidian Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology &amp; National Center of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Gang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology &amp; National Center of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Feng","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology &amp; National Center of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology &amp; National Center of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-134X","authenticated-orcid":false,"given":"Yue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology &amp; National Center of Stomatology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20582"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1089-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2019-0028"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14660"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30435"},{"key":"e_1_2_11_8_1","volume-title":"Evaluation and Treatment of Swallowing Disorders","author":"Dou Z. 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