{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:04:45Z","timestamp":1784772285202,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obstructive sleep apnea (OSA) is a common sleep\u2010related breathing disorder. Continuous positive airway pressure (CPAP) and mandibular advancement devices (MADs) are both established treatment options.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate and compare the long\u2010term objective and subjective therapeutic efficacy of MADs and CPAP in adults with OSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010nine patients diagnosed with OSA based on polysomnography (PSG) and the apnea\u2010hypopnea index (AHI) were enrolled and allocated to either MAD (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) or CPAP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200929) treatment groups. Follow\u2010up PSGs were conducted at 1 and 5\u2009years for MAD users, with their devices in\u00a0situ, while CPAP data were obtained from the device data card. Adherence, daytime sleepiness, and quality of life were assessed throughout the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At five years, 44 patients (22 MAD, 22 CPAP) remained in the study. Mean AHI significantly decreased from 31.83\u2009\u00b1\u200916.57 to 9.01\u2009\u00b1\u20095.14 episodes\/h (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in the MAD group, and from 35.11\u2009\u00b1\u200912.25 to 3.47\u2009\u00b1\u20093.12 episodes\/h (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in the CPAP group. Self\u2010reported adherence averaged 7.29\u2009\u00b1\u20091.12\u2009h\/night for MAD, while CPAP adherence averaged 4.94\u2009\u00b1\u20091.68\u2009h\/night. Daytime sleepiness and quality of life improved in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CPAP and MADs demonstrated both sustained long\u2010term efficacy in treating OSA and comparable improvements in subjective outcomes. CPAP was significantly more effective in reducing AHI, and MADs were associated with better adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70142","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:44:41Z","timestamp":1767095081000},"page":"858-865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010Term Therapeutic Efficacy of Mandibular Advancement Device Compared to Continuous Positive Airway Pressure in Patients With Obstructive Sleep Apnea"],"prefix":"10.1111","volume":"53","author":[{"given":"Evgenia Sp.","family":"Gogou","sequence":"first","affiliation":[{"name":"Orofacial Pain Clinic, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasileios","family":"Psarras","sequence":"additional","affiliation":[{"name":"Orofacial Pain Clinic, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliki","family":"Minaritzoglou","sequence":"additional","affiliation":[{"name":"Center of Sleep Disorders, Medical School of National and Kapodistrian University of Athens Dept of Critical Care and Pulmonary Services, Evaggelismos Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Kalodoukas","sequence":"additional","affiliation":[{"name":"Orofacial Pain Clinic, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail Ger.","family":"Tzakis","sequence":"additional","affiliation":[{"name":"Orofacial Pain Clinic, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6506"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2010.02.005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.23079"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41105-021-00353-6"},{"issue":"2","key":"e_1_2_12_6_1","first-page":"398","article-title":"Mandibular Advancement Devices in Obstructive Sleep Apnea: An Updated Review","volume":"15","author":"Manetta I. 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