{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T07:01:25Z","timestamp":1780642885528,"version":"3.54.1"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006378","name":"Universitas Indonesia","doi-asserted-by":"publisher","award":["NKB\u2010745\/UN2.RST\/HKP.05.00\/2024"],"award-info":[{"award-number":["NKB\u2010745\/UN2.RST\/HKP.05.00\/2024"]}],"id":[{"id":"10.13039\/501100006378","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015517","name":"Universitas Negeri Malang","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015517","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dysgeusia is a frequent yet underrecognised complication among head and neck cancer (HNC) patients, adversely affecting nutritional intake, psychological well\u2010being and quality of life. Accurate prevalence estimates are essential to guide supportive care interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This meta\u2010analysis aimed to determine the global pooled prevalence of dysgeusia in HNC patients and identify potential moderators influencing prevalence estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A systematic review and meta\u2010analysis was conducted following MOOSE and PRISMA 2020 guidelines. Online databases were searched in March 2024 across Embase, PubMed and Scopus without restrictions on region, language, or publication year. Eligible studies reported prevalence of dysgeusia using subjective or objective assessments. Pooled prevalence was estimated using a generalised linear mixed model with a random\u2010effects approach. Heterogeneity was assessed with\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      and\n                      <jats:italic>Q<\/jats:italic>\n                      statistics. Moderator analyses explored sources of heterogeneity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010three studies involving 4805 HNC patients (mean age 59.8\u2009\u00b1\u200913.1\u2009years) were included. The pooled prevalence of dysgeusia was 42.7% (95% CI, 29.7\u201356.9;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092099). Sensitivity analyses confirmed the robustness of these findings. The highest prevalence was observed in Asia (52.7%), followed by North America (41.4%) and South America (37.5%). Moderator analysis showed that older age, male sex, advanced disease stage (III\u2013IV) and the use of diverse measurement tools significantly moderated the pooled prevalence of dysgeusia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dysgeusia affects approximately half of HNC patients. Incorporating routine screening and targeted management of dysgeusia into survivorship care may help reduce nutritional risks, improve quality of life and support long\u2010term rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Significance<\/jats:title>\n                    <jats:p>Dysgeusia is highly prevalent in HNC patients, with important implications for nutrition, adherence to treatment and psychosocial well\u2010being. Routine assessment and evidence\u2010based interventions for dysgeusia should be integrated into multidisciplinary oral rehabilitation programmes to optimise patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70147","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T12:24:12Z","timestamp":1768393452000},"page":"900-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Dysgeusia in Head and Neck Cancer Patients: A Meta\u2010Analysis and Moderator Analysis"],"prefix":"10.1111","volume":"53","author":[{"given":"Yati","family":"Afiyanti","sequence":"first","affiliation":[{"name":"Department of Maternity and Women Health Nursing, Faculty of Nursing Universitas Indonesia  Depok Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masita","family":"Mandasari","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dentistry Universitas Indonesia  Depok Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri Rahayu","family":"Lestari","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Mathematics and Natural Sciences Universitas Negeri Malang  Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina Anisa","family":"Nasution","sequence":"additional","affiliation":[{"name":"Doctoral in Nursing Program, Faculty of Nursing Universitas Indonesia  Depok Indonesia"},{"name":"Study Program of Nursing, Faculty of Sport and Health Education Universitas Pendidikan Indonesia  Bandung Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Made Satya Nugraha","family":"Gautama","sequence":"additional","affiliation":[{"name":"Department of Nursing, Faculty of Medicine Universitas Pendidikan Ganesha  Singaraja Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida Ayu Md. 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