{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:41:20Z","timestamp":1789270880982,"version":"build-2803163510"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent research suggests a potential link between tooth loss and cognitive decline among the elderly population, but longitudinal evidence remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This meta\u2010analysis aims to investigate the longitudinal relationship between dentition status (tooth loss\/edentulism) and cognitive outcomes (dementia\/MCI) in aging populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      A systematic search was conducted across PubMed, Scopus, and Web of Science up to February 2025. Twenty\u2010one longitudinal studies (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200935\u2009744\u2009989 participants) meeting inclusion criteria were analysed. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random\u2010 or fixed\u2010effects models. Study quality was assessed via the Newcastle\u2010Ottawa Scale.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Longitudinal evidence supports a connection between tooth loss and cognitive decline. Specifically, tooth loss was associated with increased risks of dementia (OR\u2009=\u20091.26 [1.07, 1.49]) and MCI (OR\u2009=\u20091.40 [1.14, 1.71]). Edentulism showed higher risks (dementia: OR\u2009=\u20091.16 [1.09, 1.23]; MCI: OR\u2009=\u20091.90 [1.07, 3.35]). Subgroup analyses revealed greater risks in women and Western populations. Denture use mitigated dementia risk in individuals with tooth loss (OR\u2009=\u20091.03 [0.82, 1.28]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Tooth loss may accelerate cognitive decline, with more severe loss correlating to greater deterioration. Dentures could help mitigate this effect by restoring chewing function. Given that tooth loss is a modifiable risk factor for cognitive impairment, preventive dental care and timely prosthodontic treatment may play a protective role in maintaining brain health among older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70149","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:50:07Z","timestamp":1768827007000},"page":"924-938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Dentition\u2010Cognition Relationship in Aging Populations: A Meta\u2010Analysis of Longitudinal Data"],"prefix":"10.1111","volume":"53","author":[{"given":"Huimin","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Restorative Dental Sciences, Faculty of Dentistry The University of Hong Kong  Hong Kong SAR P.R. 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