{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:10:42Z","timestamp":1783930242054,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005089","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7222075"],"award-info":[{"award-number":["7222075"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peripheral nerve injury (PNI) often causes persistent sensory and motor deficits because of incomplete axonal regeneration and insufficient remyelination. Schwann cells (SCs) are essential for peripheral nerve repair, but effective recovery depends on their timely transition from a repair state to a myelinating phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective(s)<\/jats:title>\n                    <jats:p>To investigate whether KDM2B\u2010PP1, a bioactive peptide designed to disrupt the interaction between lysine\u2010specific demethylase 2B (KDM2B) and enhancer of zeste homologue 2 (EZH2), promotes SC redifferentiation, remyelination, and functional recovery after PNI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Primary rat SCs were treated with KDM2B\u2010PP1 in\u00a0vitro. Myelin\u2010related gene and protein expression were assessed by PCR array, qPCR, Western blotting, and ELISA. The effects of KDM2B\u2010PP1 on SC proliferation, apoptosis, and migration were also examined. A rat facial nerve transection model was used to evaluate the effects of local KDM2B\u2010PP1 administration on remyelination, nerve structure, and functional recovery in\u00a0vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>KDM2B\u2010PP1 disrupted the KDM2B\u2013EZH2 interaction and relieved EZH2\u2010mediated repression of myelin\u2010related genes. In SCs, KDM2B\u2010PP1 increased the expression of myelin\u2010associated transcripts and proteins, including Olig1, and promoted redifferentiation toward a myelinating phenotype. In\u00a0vivo, local administration of KDM2B\u2010PP1 enhanced myelin sheath formation, improved nerve architecture, and promoted late\u2010stage functional recovery after facial nerve injury. KDM2B\u2010PP1 did not significantly affect SC proliferation, apoptosis, or migration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>KDM2B\u2010PP1 is a novel epigenetic modulator that selectively promotes SC\u2010mediated remyelination and functional recovery after peripheral nerve injury. These findings provide new insight into the epigenetic regulation of peripheral nerve regeneration and support KDM2B\u2010PP1 as a potential therapeutic candidate for PNI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70203","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:25:53Z","timestamp":1777033553000},"page":"1517-1529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>KDM2B<\/scp>\n                    \u2010\n                    <scp>PP1<\/scp>\n                    Promotes Remyelination and Functional Recovery After Facial Nerve Injury"],"prefix":"10.1111","volume":"53","author":[{"given":"Huiyue","family":"Xu","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Stomatological Hospital School of Stomatology, Capital Medical University  Beijing 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