{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:28:54Z","timestamp":1789756134518,"version":"4.0.1"},"reference-count":67,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2026,8]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Post\u2010traumatic trigeminal neuropathic pain (PTNP) is a debilitating orofacial pain disorder most commonly caused by trigeminal nerve injury after dental procedures or facial trauma. Available systemic therapies have modest and inconsistent efficacy, with substantial tolerability concerns limiting adherence.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To evaluate the real\u2010world effectiveness and tolerability of a compounded intraoral mucoadhesive gel containing amitriptyline 10% plus lidocaine 2% in adults with PTNP.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective real\u2010world evidence study included adults with\n PTNP<\/jats:styled-content>\n meeting\n ICHD<\/jats:styled-content>\n \u20103\/\n ICOP<\/jats:styled-content>\n criteria who were treated at a tertiary orofacial pain clinic from May 1, 2023, to April 30, 2024. The primary outcome was the within\u2010patient change in pain intensity on a 0\u201310 numerical rating scale (\n NRS<\/jats:styled-content>\n ) from baseline to week 8. Secondary outcomes included responder rates (\u2265\u200950% and\u2009\u2265\u200930% pain reduction), patient global impression of improvement (\n PGI<\/jats:styled-content>\n \u2010I) and adverse events (\n AEs<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 94 patients identified, 40 were included in the complete\u2010case initiator cohort. Mean pain intensity decreased from 6.3\u2009\u00b1\u20091.7 at baseline to 3.0\u2009\u00b1\u20092.7 at week 8, corresponding to a mean within\u2010patient reduction of 3.30 points (95%\n CI,<\/jats:styled-content>\n 2.51\u20134.09;\n p<\/jats:italic>\n \u2009<\u20090.001). Twenty\u2010two of 40 patients (55%; 95%\n CI,<\/jats:styled-content>\n 40\u201369) achieved a \u2265\u200950% reduction in pain intensity, and 27 of 40 (68%; 95%\n CI,<\/jats:styled-content>\n 52\u201380) achieved a \u2265\u200930% pain reduction. Seventy\u2010five percent (30\/40, 95%\n CI,<\/jats:styled-content>\n 60\u201386) reported overall improvement on the\n PGI<\/jats:styled-content>\n \u2010I. Mild treatment\u2010related\n AEs<\/jats:styled-content>\n occurred in five of 40 patients (12%); no serious\n AEs<\/jats:styled-content>\n or treatment discontinuations were reported.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In this retrospective real\u2010world study, topical amitriptyline\u2013lidocaine mucoadhesive gel was associated with statistically significant and clinically meaningful pain improvement in adults with\n PTNP<\/jats:styled-content>\n , together with favourable tolerability. These findings support targeted mucosal delivery as a promising local therapeutic option and potential medication\u2010sparing strategy, particularly when systemic therapies are ineffective or poorly tolerated. Randomized controlled trials are now needed to confirm efficacy and clarify the role of topical amitriptyline in\n PTNP<\/jats:styled-content>\n treatment pathways and routine clinical care.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/joor.70209","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T05:41:21Z","timestamp":1778046081000},"page":"1550-1561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness and Tolerability of Topical Amitriptyline 10% Plus Lidocaine 2% Gel in Adults With Post\u2010Traumatic Trigeminal Neuropathic Pain: A Real\u2010World Evidence Study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-3650","authenticated-orcid":false,"given":"Ashley","family":"Lebel","sequence":"first","affiliation":[{"name":"Department of Orofacial Pain Institute of Dental Surgery, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital (AP\u2010HP) Paris France"},{"name":"Laboratory of Orofacial Neurobiology Inserm UMR1333 Oral Heath, Universit\u00e9 Paris Cit\u00e9 Montrouge France"},{"name":"Gene Regulation and Adaptive Behaviors Center for Neuroscience Sorbonne University (NeuroSU), Sorbone Universit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Stambouli","sequence":"additional","affiliation":[{"name":"Unit of Orofacial Pain and Temporomandibular Dysfunction University Dental Clinic Monastir Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6182-0860","authenticated-orcid":false,"given":"Yves","family":"Boucher","sequence":"additional","affiliation":[{"name":"Department of Orofacial Pain Institute of Dental Surgery, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital (AP\u2010HP) Paris France"},{"name":"Laboratory of Orofacial Neurobiology Inserm UMR1333 Oral Heath, Universit\u00e9 Paris Cit\u00e9 Montrouge 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