{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:04:34Z","timestamp":1789625074098,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170967"],"award-info":[{"award-number":["82170967"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This pilot study was designed to analyze salivary proteomic and microbiome profile in burning mouth syndrome (BMS) and to explore the potential role of salivary mucins in barrier\u2010related host\u2013microbe interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Unstimulated saliva samples from BMS patients and healthy controls were analyzed using data\u2010independent acquisition (DIA)\u2010based proteomics and 16S rRNA gene sequencing. A multi\u2010step strategy was applied to identify BMS\u2010associated core salivary proteins. Biofilm formation, epithelial adhesion and injury, as well as molecular permeability using a transwell model were conducted to assess the mucosal barrier\u2013microbe interactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Proteomic profiling defined 29 BMS\u2010associated core proteins with MUC5B showing prominent differential expression. Microbiome analysis showed altered community structure in BMS saliva, including increased relative abundance of\n                      <jats:italic>Rothia<\/jats:italic>\n                      . Further in\u00a0vitro explorations revealed that mucin triggered dispersal of the formed biofilms, reduced bacterial adhesion to oral epithelial cells, attenuated epithelial cell injury and decreased FITC\u2013dextran permeability in a concentration\u2010dependent manner.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      BMS might be associated with mucin\u2010related alterations in the salivary microenvironment, including reduced MUC5B and increased relative abundance of\n                      <jats:italic>Rothia<\/jats:italic>\n                      . Together with the in\u00a0vitro findings, this might suggest that mucin\u2010related barrier changes may be linked to altered host\u2013microbe interactions in BMS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70242","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:46:36Z","timestamp":1781523996000},"page":"1836-1847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salivary Proteome\u2013Microbiome Profiling in Burning Mouth Syndrome Might Highlight Mucin\u2010Related Host\u2013Microbe Features"],"prefix":"10.1111","volume":"53","author":[{"given":"Yajuan","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Oral Medicine Peking University School and Hospital of Stomatology  Beijing China"},{"name":"National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; National Engineering Research Center of Oral Biomaterials and Digital Medical Devices  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linman","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine Peking University School and Hospital of Stomatology  Beijing China"},{"name":"National Center for Stomatology &amp; 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