{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:04:33Z","timestamp":1789625073924,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Migraine has been associated with altered nociceptive processing and may influence the clinical presentation of odontogenic pain. This study evaluated whether migraine is associated with preoperative endodontic pain, somatosensory function, and short\u2010term pain outcomes after root canal treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective observational study, 72 patients with symptomatic irreversible pulpitis requiring nonsurgical root canal treatment were classified into two groups: patients with neurologist\u2010confirmed migraine assessed during the interictal phase and patients without migraine. The primary outcome was preoperative pain intensity, assessed using a 0\u201310 visual analogue scale (VAS). Additional secondary outcomes included mechanical detection threshold (MDT), mechanical pain threshold (MPT), mechanical pain sensitivity (MPS), pain during cold testing and needle penetration, and post\u2010endodontic pain recorded at 6, 12, 24, 48, and 72\u2009h. MDT, MPT, and MPS were assessed at the dorsal hand as an extracephalic reference site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with migraine with endodontic pain reported significantly greater preoperative endodontic pain than those without migraine (VAS: 6.39\u2009\u00b1\u20092.04 vs. 4.20\u2009\u00b1\u20092.88;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0005). Secondary analyses showed MDT was significantly higher in the migraine group before and after treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), suggesting altered mechanical detection. MPT, MPS, Pain test score, Needle penetration Pain and short\u2010term post\u2010endodontic pain did not differ significantly between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Migraine patients with endodontic pain exhibited higher preoperative endodontic pain severity and elevated mechanical detection thresholds (MDT) compared to non\u2010migraine patients, whereas other sensory measures (MPT, MPS) showed no significant differences. These findings suggest selective alterations in pain perception and tactile sensitivity in migraine patients, rather than a broad generalised sensory abnormality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70249","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:28:14Z","timestamp":1782397694000},"page":"1913-1922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Migraine is Associated With Altered Preoperative Endodontic Pain Perception and Mechanical Sensory Function but Not Short\u2010Term Postoperative Pain: A Prospective Clinical Study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3501-0538","authenticated-orcid":false,"given":"Abu Saeed Ibn","family":"Harun","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Chattagram International Dental College  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9387-5882","authenticated-orcid":false,"given":"Abu Hena Mohammod Zakir Hossain","family":"Shikder","sequence":"additional","affiliation":[{"name":"Department of Paediatric Dentistry Bangladesh Medical University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1726-1696","authenticated-orcid":false,"given":"Suparna Dutta","family":"Moni","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Chattagram International Dental College  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2353-7618","authenticated-orcid":false,"given":"Nazneen","family":"Karim","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics Chattagram International Dental College  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5988-2143","authenticated-orcid":false,"given":"Mohammed","family":"Asaduzzaman","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry &amp; Endodontics Bangladesh Medical University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.70232"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13029"},{"key":"e_1_2_11_4_1","first-page":"235","article-title":"The Dimension and Severity of Orofacial Pain in Current and Chronic Odontogenic Pain Condition","volume":"41","author":"ASI H.","year":"2021","journal-title":"M.D. Journal"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002657"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665\u20109913(21)00032\u20101"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010022\u201000763\u20101"},{"key":"e_1_2_11_8_1","unstructured":"World Health Organization \u201cMigraine and Other Headache Disorders. Fact Sheet \u201d2025 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail."},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S329280"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.09.006"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.80.5.2621"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.90a.22019"},{"key":"e_1_2_11_13_1","unstructured":"P.Mohebbi M.Vatanpour andM.Najarian Toushi \u201cRelationship Between Migraine and Pre\u2010 and Post\u2010Operative Pain Following Root Canal Treatment \u201dIranian Division Meeting 2017 Tehran Iran https:\/\/my.iadr.org\/NC__Login."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781584887409"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781315183084"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.801437"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.70584"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010024\u201001932\u2010x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001231"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.5935\/1806\u20100013.20160044"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.2"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002830"},{"issue":"6","key":"e_1_2_11_25_1","first-page":"983","article-title":"The Trigeminovascular Pathway: Role of CGRP and CGRP Receptors in Migraine","volume":"57","author":"Edvinsson L.","year":"2017","journal-title":"Headache"},{"issue":"1","key":"e_1_2_11_26_1","first-page":"S1","article-title":"Migraine Pathophysiology: Anatomy of the Trigeminovascular Pathway and Associated Neurological Symptoms, Cortical Spreading Depression, Sensitization and Modulation of Pain","volume":"154","author":"Noseda R.","year":"2013","journal-title":"Pain"},{"key":"e_1_2_11_27_1","first-page":"S2","article-title":"Neurovascular Mechanisms in Migraine","volume":"32","author":"Moskowitz M. 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