{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:55:57Z","timestamp":1790182557197,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QH491"],"award-info":[{"award-number":["ZR2024QH491"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sleep bruxism (SB) is a sleep\u2010related movement behaviour with potential dental and orofacial consequences. Pharmacologic treatment remains controversial because evidence of benefit is limited and its clinical value in dental practice is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the efficacy, safety and clinical relevance of pharmacologic interventions for SB in adults, and to consider their implications for dental management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Embase and Web of Science were searched through March 2025. Clinical trials in adults were eligible when they evaluated pharmacologic interventions for polysomnography\u2010confirmed SB or rhythmic masticatory muscle activity (RMMA). Randomized studies were synthesized quantitatively where appropriate, and non\u2010randomized studies were summarized qualitatively. Risk of bias and certainty of evidence were assessed using standard review methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine studies involving 116 adults were included, six of which were randomized crossover trials. Five pharmacologic classes were identified. Overall certainty of evidence ranged from low to very low. Clonidine showed the most consistent, but modest, reduction in SB frequency. Benzodiazepines, dopaminergic agents and beta\u2010blockers showed no reproducible benefit. Gabapentin reduced RMMA and improved sleep efficiency in one non\u2010randomized study. No serious adverse events were reported, but most studies evaluated only single\u2010night or short\u2010term exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Current evidence suggests that pharmacological interventions provide, at most, limited short\u2010term benefits for SB. For dental practice, pharmacotherapy should not replace established first\u2010line approaches such as patient counselling, behavioural strategies and occlusal appliances. At present, no medication can be recommended for routine management of SB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO Registration<\/jats:title>\n                    <jats:p>CRD420251168064.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70254","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T05:51:22Z","timestamp":1783317082000},"page":"1783-1796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacologic Management of Sleep Bruxism in Adults: A Systematic Review and Meta\u2010Analysis of Polysomnographic Outcomes"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4216-0240","authenticated-orcid":false,"given":"Deshui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Cheeloo College of Medicine, Shandong University &amp; Shandong Key Laboratory of Oral Diseases &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Cheeloo College of Medicine, Shandong University &amp; Shandong Key Laboratory of Oral Diseases &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanliang","family":"Sun","sequence":"additional","affiliation":[{"name":"National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Jiayi","sequence":"additional","affiliation":[{"name":"School of Stomatology, Cheeloo College of Medicine Shandong University &amp; Shandong Key Laboratory of Oral Diseases &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6827-8293","authenticated-orcid":false,"given":"Fulan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, School and Hospital of Stomatology Cheeloo College of Medicine, Shandong University &amp; Shandong Key Laboratory of Oral Diseases &amp; Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration &amp; Shandong Provincial Clinical Research Center for Oral Diseases  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13985"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13144259"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40675\u2010018\u20100105\u20108"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.17219\/dmp\/201376"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.17219\/dmp\/191517"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpor.2019.04.012"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.11.017"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345980770040901"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102842.2011.02203.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.2021.1904181"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11682\u2010021\u201000601\u2010w"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202502015R"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.13983"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2019.07.017"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2022.02.004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/29.3.307"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.12.1711"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406\u2010009\u20100034\u20100"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085917"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12442"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prosdent.2020.11.028"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12440"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u2010849X.2012.00914.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11020146"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_27_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5","author":"Higgins J. 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