{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:15:15Z","timestamp":1790709315597,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review aimed to evaluate the effectiveness of myofascial release therapy (MFR) on pain in patients affected by myogenous temporomandibular disorders (TMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Scopus, and Web of Science were searched from inception until 31 January 2026, to identify RCTs including patients affected by TMD as participants, MFR therapy as intervention, and pain intensity as outcome. The risk of bias of studies was assessed with the Version 2 of the Cochrane risk\u2010of\u2010bias tool for randomized trials (RoB 2). The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to assess the certainty of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Out of 857 articles, 7 studies were included. All subjects had a diagnosis of TMD performed according to the RDC\/TMD or DC\/TMD. The rehabilitation period ranged from 10\u2009days to 5\u2009weeks. Treatment frequency ranged from a minimum of one session per week to a maximum of 3 sessions per week. Medium\/long\u2010term follow\u2010up was performed in four studies. The Cochrane RoB 2 tool showed that zero studies had a low risk of bias, six had some concerns, and one had a high risk of bias. The GRADE assessment showed a low certain of evidence for pain reduction and mouth function, and a very low certain of evidence in improving QoL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MFR seemed to reduce pain and improve mouth function in patients with myogenous TMD. However, when benchmarked against established clinical thresholds, clinically meaningful efficacy (surpassing the 15\u201322\u2009mm MCID) is only supported by a subset of the included trials. In this context, MFR could be considered as part of a multidisciplinary approach for patients with TMD. More rigorous isolated\u2010MFR trials are needed to better characterize the efficacy of MFR in patients affected by myogenous TMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70271","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:54:58Z","timestamp":1784174098000},"page":"1972-1984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Myofascial Release Therapy and Related Soft\u2010Tissue Techniques for Pain in Temporomandibular Disorders: A Systematic Review of Randomized Controlled Trials"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1878-4694","authenticated-orcid":false,"given":"Martina","family":"Ferrillo","sequence":"first","affiliation":[{"name":"Dentistry Unit, Department of Health Sciences University of Catanzaro \u201cMagna Graecia\u201d  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9221-2497","authenticated-orcid":false,"given":"Dario","family":"Calafiore","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Unit, Department of Neuroscience ASST Carlo Poma  Mantova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"De Rosa","sequence":"additional","affiliation":[{"name":"Department of Life Science, Health and Health Professions Link Campus University  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3269-3510","authenticated-orcid":false,"given":"Ambra","family":"Sedran","sequence":"additional","affiliation":[{"name":"Dental School, Department of Surgical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umile Giuseppe","family":"Longo","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario Campus Bio\u2010Medico  Roma Italy"},{"name":"Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery Universit\u00e0 Campus Bio\u2010Medico di Roma  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5254-3283","authenticated-orcid":false,"given":"Michele","family":"Vecchio","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences University of Catania  Catania Italy"},{"name":"Physical Medicine and Rehabilitation Unit, AOU Policlinico G. Rodolico University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-2455","authenticated-orcid":false,"given":"Antonio","family":"Ammendolia","sequence":"additional","affiliation":[{"name":"Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG University of Catanzaro \u201cMagna Graecia\u201d  Catanzaro Italy"},{"name":"Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences University of Catanzaro \u201cMagna Graecia\u201d  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7380-1675","authenticated-orcid":false,"given":"Nicola","family":"Scotti","sequence":"additional","affiliation":[{"name":"Dental School, Department of Surgical Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5091-6979","authenticated-orcid":false,"given":"Amerigo","family":"Giudice","sequence":"additional","affiliation":[{"name":"Dentistry Unit, Department of Health Sciences University of Catanzaro \u201cMagna Graecia\u201d  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5541-8346","authenticated-orcid":false,"given":"Alessandro","family":"de Sire","sequence":"additional","affiliation":[{"name":"Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG University of Catanzaro \u201cMagna Graecia\u201d  Catanzaro Italy"},{"name":"Physical Medicine and Rehabilitation Unit, Department of Medical and Surgical Sciences University of Catanzaro \u201cMagna Graecia\u201d  Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2015.02.007"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2023.12.010"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.22514\/jocpd.2023.001"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891\u2010024\u201008196\u20101"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345251376295"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2024.09.015"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2021.07.029"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.11607\/jop.1151"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20170389"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2025.103923"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.70126"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010020\u201003710\u2010w"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/joor.12661"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/08869634.2022.2126079"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2024.05.008"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2021.102737"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbmt.2023.04.085"},{"key":"e_1_2_12_19_1","volume-title":"The Myofascial Release Manual","author":"Manheim C. 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