{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:29:15Z","timestamp":1786501755892,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temporomandibular disorders (TMD) have the potential to progress to a chronic form associated with various comorbidities. Prolonged symptoms may lead to central sensitization (CS), resulting in decreased treatment response and highlighting the need for personalized treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study evaluated psychological conditions and comorbidities in TMD patients based on CS\u2010related symptom levels measured by the Central Sensitization Inventory (CSI) and investigated the association between these levels and long\u2010term treatment outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      CS\u2010related symptom levels were assessed using the CSI in 112 TMD patients (score \u2265\u200940 indicating significant levels of CS symptoms). Psychological, sleep, autonomic and pain\u2010related comorbidities were evaluated by validated questionnaires. Participants received standardized conservative treatment, including behavioural, physical, stabilization splint and pharmacological therapies. After 6\u2009months, patients were re\u2010evaluated for clinical signs. Data were statistically compared between the high (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940) and low (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200972) CSI groups and associations between clinical characteristics and CSI levels were analyzed. Longitudinal changes were analyzed using Generalized Estimating Equations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      High CSI (35.7%) was associated with higher McGill Pain Questionnaire (MPQ) scores, widespread pain and higher levels of anxiety, depression, somatization and autonomic symptoms (all\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>adj<\/jats:sub>\n                      \u2009&lt;\u20090.05 after Bonferroni correction). At 6\u2010month follow\u2010up, the high CSI group showed a trend toward a smaller reduction in pain (group \u00d7 time interaction, \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20095.587,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018), suggesting a potentially less favourable treatment response to conservative therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TMD patients with higher CSI scores exhibit more multidimensional comorbidities and diminished response to conservative therapy. Early identification of CS\u2010related symptoms may be beneficial for establishing personalized treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70287","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T02:04:52Z","timestamp":1786500292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Central Sensitization on Long\u2010Term Prognosis and Comorbidity Levels in Temporomandibular Disorders: A Prospective Longitudinal Study"],"prefix":"10.1111","author":[{"given":"Seok Jin","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Oral Diagnosis, School of Dentistry Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2296-9579","authenticated-orcid":false,"given":"Youngwoo","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Oral Diagnosis, School of Dentistry Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5408-8437","authenticated-orcid":false,"given":"Jung Hwan","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Oral Diagnosis, School of Dentistry Seoul National University  Seoul Korea"},{"name":"Department of Oral Medicine Seoul National University Dental Hospital  Seoul Korea"},{"name":"Dental Research Institute Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-755X","authenticated-orcid":false,"given":"Prangtip","family":"Potewiratnanond","sequence":"additional","affiliation":[{"name":"Department of Occlusion, Faculty of Dentistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-7021","authenticated-orcid":false,"given":"Ji Woon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Oral Diagnosis, School of Dentistry Seoul National University  Seoul Korea"},{"name":"Department of Oral Medicine Seoul National University Dental Hospital  Seoul Korea"},{"name":"Dental Research Institute Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"issue":"6","key":"e_1_2_11_2_1","first-page":"378","article-title":"Diagnosis and Treatment of Temporomandibular Disorders","volume":"91","author":"Gauer R. 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