{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:08:17Z","timestamp":1789967297833,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["444361\/2024\u20103"],"award-info":[{"award-number":["444361\/2024\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006416","name":"Universidade Estadual de Campinas","doi-asserted-by":"publisher","award":["01\/2023"],"award-info":[{"award-number":["01\/2023"]}],"id":[{"id":"10.13039\/501100006416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Salivary parameters are clinically relevant for complete denture (CD) lubrication, comfort, retention, and adaptation in edentulous patients. Although an immediate salivary response following CD insertion is biologically plausible, the magnitude and persistence of changes in salivary flow,\u00a0pH, and biomarkers after treatment remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether the installation of new CDs influences salivary parameters (flow rate, pH and biomarkers) in edentulous patients, both under stimulated and unstimulated conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five databases were searched to identify clinical studies comparing total salivary flow, salivary pH and biomarkers before and after CD installation. The ROBINS\u2010I tool was used to assess risk of bias, and Comprehensive Meta\u2010Analysis software (version 3.2) was used to perform the meta\u2010analysis; biomarker data were synthesized descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010two studies were selected, comprising 645 edentulous patients rehabilitated with\n                      <jats:styled-content style=\"fixed-case\">CDs<\/jats:styled-content>\n                      , evaluated immediately after\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      installation and at 2\u20133\u2009months. Eight were included in the quantitative analysis. Six studies had a serious risk of bias, and 16 had a critical risk. The meta\u2010analyses showed significant increases in both stimulated and unstimulated salivary flow, as well as in salivary\n                      <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                      , immediately after\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      insertion and after 2\u20133\u2009months of use (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Descriptive analysis revealed time\u2010dependent changes in salivary biomarkers for inflammation, oxidative stress and immunity following\n                      <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                      installation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CD installation increased salivary flow, both stimulated and unstimulated, and salivary pH over time, with biological changes reflected by salivary biomarkers. However, because of the high risk of bias, these findings should be interpreted with caution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70310","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:46:24Z","timestamp":1789965984000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salivary Parameters Before and After Removable Complete Denture Rehabilitation: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","author":[{"given":"C\u00e1tia Sufia Alves Freire","family":"de Andrade","sequence":"first","affiliation":[{"name":"Department of Prosthodontics and Periodontology, Piracicaba Dental School Universidade Estadual de Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-6449","authenticated-orcid":false,"given":"Mariana Alves","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontology, Piracicaba Dental School Universidade Estadual de Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirtes Maria Ferreira","family":"Corr\u00eaa","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontology, Piracicaba Dental School Universidade Estadual de Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7171-2864","authenticated-orcid":false,"given":"Ayrton Geroncio","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontology, Piracicaba Dental School Universidade Estadual de Campinas (UNICAMP)  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Egumi","family":"Nagay","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontology, Bauru School of Dentistry University of S\u00e3o Paulo (USP)  Bauru S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6391-9917","authenticated-orcid":false,"given":"Valentim A. 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