{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:59:15Z","timestamp":1790301555633,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temporomandibular joint osteoarthritis (TMJ\u2010OA) is a degenerative condition that negatively affects quality of life. Although platelet\u2010rich plasma (PRP) is widely used, its efficacy remains controversial. Autologous conditioned serum (ACS), which targets inflammation via interleukin\u20101 receptor antagonist (IL\u20101Ra), has emerged as a novel biological therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare the effects of two autologous biological agents, PRP and ACS, used as adjuncts to arthrocentesis, on pain, maximum mouth opening (MMO) and joint sounds in patients with TMJ\u2010OA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This randomized, single\u2010centre clinical trial with blinded outcome assessment and statistical analysis included 75 patients with TMJ\u2010OA. Participants were allocated to three groups: ACS, PRP and control (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925 each). All patients underwent arthrocentesis; the ACS and PRP groups received 1\u2009mL intra\u2010articular injections, while the control group received no additional treatment. Outcomes were assessed at baseline, 1\u2009week, 1\u2009month, 3\u2009months and 6\u2009months by a blinded assessor. Pain was evaluated using a visual analogue scale (VAS), MMO was measured in millimetres and joint sounds were clinically assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline characteristics were comparable among the groups. From the first week onward, significant differences in VAS and MMO were observed at all follow\u2010up time points (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Both ACS and PRP groups demonstrated greater improvement compared to the control group. However, no consistent statistically significant differences were observed between the two treatment groups. Joint sounds decreased significantly in both treatment groups, particularly at later follow\u2010up periods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both ACS and PRP following arthrocentesis improved clinical outcomes in TMJ\u2010OA, with no consistent superiority between treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      : NCT06839326\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70314","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:15:45Z","timestamp":1790298945000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Autologous Conditioned Serum and Platelet\u2010Rich Plasma Following Arthrocentesis in Temporomandibular Joint Osteoarthritis: A Randomized Clinical Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6716-5075","authenticated-orcid":false,"given":"Rojdan Ferman G\u00fcne\u015f","family":"Uysal","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Faculty of Dentistry Batman University  Batman T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2470-8906","authenticated-orcid":false,"given":"Ibrahim","family":"Uysal","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry Dicle University  Diyarbak\u0131r T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"issue":"1","key":"e_1_2_14_2_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s13191-013-0321-3","article-title":"Temporomandibular Joint Osteoarthritis: Diagnosis and Long\u2010Term Conservative Management: A Topic Review","volume":"14","author":"Kalladka M.","year":"2014","journal-title":"Journal of Indian Prosthodontic Society"},{"issue":"10","key":"e_1_2_14_3_1","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.ijom.2015.06.023","article-title":"Temporomandibular Joint Osteoarthritis: Cone Beam Computed Tomography Findings, Clinical Features, and Correlations","volume":"44","author":"Kilic S. 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