{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:54:47Z","timestamp":1790996087947,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare 5\u2010year outcomes of immediate versus early loading protocols for complete implant\u2010supported fixed dental prostheses in edentulous maxillae.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      A prospective randomized controlled trial evaluated 24 patients (144 Bone Level Tapered SLActive implants) assigned to immediate loading (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912, 72 implants) or early loading (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200912, 72 implants). Outcome measures included implant and prosthesis survival rates, marginal bone loss (MBL), buccal plate thickness (BPT), implant stability (ISQ), Oral Health Impact Profile\u201019 (OHIP\u201019) and patient satisfaction (Visual Analog Scale).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the 5\u2010year follow\u2010up, 3 participants (12.5%) discontinued study participation (1 patient from the immediate loading group and 2 patients from the early loading group). Five\u2010year implant and prosthesis survival rates showed no statistically significant differences between groups. Implant survival was 98.6% with immediate loading and 97.2% with early loading (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.610), while prosthesis survival was 91.67% and 100%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.317). Buccal marginal bone loss was significantly greater in the immediate loading group (\u22121.15\u2009mm vs. \u22120.36\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). Mechanical complications occurred more frequently in the immediate loading group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). Four of five periimplantitis occurred in immediately loaded implants (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.310). Peri\u2010implant mucositis affected 55.32% of implants with equal distribution. Patient satisfaction remained high in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both immediate and early loading achieved comparable implant and prosthesis survival rates at 5\u2009years. However, immediate loading resulted in significantly greater buccal marginal bone loss. Both protocols provided excellent patient outcomes and can be considered viable options for maxillary rehabilitation with adequate primary stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This clinical trial was registered after participant recruitment and randomization (NCT07574099)<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70330","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:25:48Z","timestamp":1790994348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immediate Versus Early Loading Protocols in Rehabilitation of Fully Edentulous Maxilla: A 5\u2010Year Pilot Randomized Clinical Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-6895","authenticated-orcid":false,"given":"Vecihe Merve Balta","family":"Uysal","sequence":"first","affiliation":[{"name":"ITI Scholar, Implant Center, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-0974","authenticated-orcid":false,"given":"Aleksa","family":"Markovi\u0107","sequence":"additional","affiliation":[{"name":"Implant Center, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tijana","family":"Mi\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Oral Surgery, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miodrag","family":"\u0160\u0107epanovi\u0107","sequence":"additional","affiliation":[{"name":"Implant Center, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6429-7646","authenticated-orcid":false,"given":"Branka","family":"Trifkovi\u0107","sequence":"additional","affiliation":[{"name":"Implant Center, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7064-0922","authenticated-orcid":false,"given":"Branislav","family":"Ili\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Oral Surgery, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana R.","family":"Todorovi\u0107","sequence":"additional","affiliation":[{"name":"Implant Center, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3120-0673","authenticated-orcid":false,"given":"Jovana","family":"Markovi\u0107","sequence":"additional","affiliation":[{"name":"Implant Center, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel M.","family":"Dard","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojan","family":"Janji\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Oral Surgery, School of Dental Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"132","article-title":"Loading Protocols for Dental Implants in Edentulous Patients","volume":"24","author":"Gallucci G. 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