{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:37:51Z","timestamp":1792831071751,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:00:00Z","timestamp":1792800000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["25\/07635\u20109"],"award-info":[{"award-number":["25\/07635\u20109"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Oral Rehabilitation"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Temporomandibular disorders (TMD) may be accompanied by adaptive and degenerative remodelling of the mandibular condyle. Although computed tomography (CT) depicts established osseous changes, quantitative assessment of trabecular bone may provide additional information on local bone organization that is not captured by morphological evaluation alone. Texture analysis offers a means of characterising these differences within the condylar trabecular compartment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether CT texture analysis can detect differences in condylar trabecular bone among patients with TMD with and without subchondral cysts and asymptomatic controls, with particular attention to peri\u2010cystic trabecular bone in condyles presenting subchondral cysts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective study, 250 CT examinations were screened, and 116 patients met the inclusion criteria. Participants were allocated into three groups: TMD with subchondral cysts (TMD\u2009+\u2009Cyst;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960), TMD without subchondral cysts (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916) and asymptomatic controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940). Eleven grey\u2010level co\u2010occurrence matrix texture features were extracted from manually defined trabecular bone regions of interest on three central sagittal slices. In the TMD\u2009+\u2009Cyst group, the ROI was positioned adjacent to the cyst, whereas in cyst\u2010free condyles it was placed in the superior subchondral trabecular bone. Group comparisons were performed using the Kruskal\u2013Wallis test with Dunn's post hoc test, false discovery rate correction and adjustment for age and gender. Receiver operating characteristic analysis evaluated the discriminatory performance of significant texture features.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four texture features remained significantly different among the groups after false discovery rate correction and adjustment for age and gender: Correlation (Correlat), Sum of Squares (SumOfSqs), Sum Variance (SumVarnc) and Sum Entropy (SumEntrp) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). In exploratory ROC analyses, Correlat showed the highest AUC for TMD\u2009+\u2009Cyst versus controls (AUC\u2009=\u20090.855). In contrast, none of the four significant texture features showed discriminatory performance statistically distinguishable from chance for TMD without Cyst versus Control, with AUCs ranging from 0.537 to 0.611 and all 95% confidence intervals including 0.5. Significant pairwise differences for the four texture features were observed between the TMD\u2009+\u2009Cyst and Control groups, whereas no significant pairwise differences were found between the TMD without Cyst and Control groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CT texture analysis detected quantitative differences in condylar trabecular bone among patients with TMD with and without subchondral cysts and asymptomatic controls. The findings indicate differences in trabecular texture particularly between peri\u2010cystic bone in the TMD\u2009+\u2009Cyst group and subchondral bone in asymptomatic controls. Because the ROIs were biologically selected but not anatomically matched across groups, the findings should be interpreted as exploratory and do not establish a temporal sequence of trabecular remodelling leading to cyst formation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/joor.70356","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:20:07Z","timestamp":1792830007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Condylar Trabecular Bone Texture in Temporomandibular Disorders: A Quantitative Computed Tomography Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6776-1766","authenticated-orcid":false,"given":"Elaine Dinardi","family":"Barioni","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry Cruzeiro do Sul University (UNICSUL)  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Larissa","family":"Oliveira do Nascimento","sequence":"additional","affiliation":[{"name":"School of Dentistry of Paulista Association of Dentists (FAOA)  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3840-5401","authenticated-orcid":false,"given":"Lana Ferreira","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery The Institute of Sciences and Technology of S\u00e3o Paulo State University (UNESP)  S\u00e3o Jos\u00e9 dos Campos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3229-8019","authenticated-orcid":false,"given":"Maria Aparecida Neves","family":"Jardini","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery The Institute of Sciences and Technology of S\u00e3o Paulo State University (UNESP)  S\u00e3o Jos\u00e9 dos Campos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6768-0176","authenticated-orcid":false,"given":"Kaan","family":"Orhan","sequence":"additional","affiliation":[{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0882-5862","authenticated-orcid":false,"given":"S\u00e9rgio Lucio Pereira de Castro","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery The Institute of Sciences and Technology of S\u00e3o Paulo State University (UNESP)  S\u00e3o Jos\u00e9 dos Campos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4856-5417","authenticated-orcid":false,"given":"Andre Luiz Ferreira","family":"Costa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry Cruzeiro do Sul University (UNICSUL)  S\u00e3o Paulo SP Brazil"},{"name":"School of Dentistry of Paulista Association of Dentists (FAOA)  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,24]]},"reference":[{"issue":"8","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00276-008-0400-z","article-title":"Comparison of Conventional MRI and 3D Reconstruction Model for Evaluation of Temporomandibular Joint","volume":"30","author":"Costa A. 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