{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:20:49Z","timestamp":1790742049512,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T00:00:00Z","timestamp":1352073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Military Medical Research","award":["08G105"],"award-info":[{"award-number":["08G105"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,4]]},"abstract":"\n Oral lichen planus (\n OLP<\/jats:styled-content>\n ) is a common oral mucosal disease, which is generally considered a potentially malignant lesion. To identify efficiently prognostic biomarker, we investigated the\n \n micro\n RNA<\/jats:styled-content>\n \u2010137\n <\/jats:italic>\n (\n \n mi\n R<\/jats:styled-content>\n \u2010137\n <\/jats:italic>\n ) promoter methylation in\n OLP<\/jats:styled-content>\n and compared with the samples from healthy volunteers and patients with oral squamous cell carcinoma (\n OSCC<\/jats:styled-content>\n ). A total of 20\n OLP<\/jats:styled-content>\n and 12 patients with\n OSCC<\/jats:styled-content>\n as well as 10 healthy subjects were subjected to\n \n mi\n R<\/jats:styled-content>\n \u2010137\n <\/jats:italic>\n promoter methylation analysis using methylation\u2010specific\n PCR<\/jats:styled-content>\n (\n MSP<\/jats:styled-content>\n ). To address the malignancy prediction potential from\n \n mi\n R<\/jats:styled-content>\n \u2010137\n <\/jats:italic>\n promoter methylation status, methylation of the\n p16<\/jats:italic>\n gene, a well\u2010known tumor suppressor, was investigated in the same samples. The\n p16<\/jats:italic>\n methylation and\n \n mi\n R<\/jats:styled-content>\n \u2010137\n <\/jats:italic>\n promoter methylation were found to be 25% and 35% in patients with\n OLP<\/jats:styled-content>\n , 50% and 58.3% in patients with\n OSCC<\/jats:styled-content>\n , and 0% and 0% in healthy subjects, respectively. The differences between\n \n mi\n R<\/jats:styled-content>\n \u2010137\n <\/jats:italic>\n and\n p16<\/jats:italic>\n methylation levels were statistically significant between healthy controls and patients. Methylation levels of the two promoters were also influenced by age, gender, and lesion duration. Interestingly, aberrant promoter methylation of the\n p16<\/jats:italic>\n and\n \n mi\n R<\/jats:styled-content>\n \u2010137\n <\/jats:italic>\n genes was only found in the epithelium but not in the connective tissue from patients with\n OLP<\/jats:styled-content>\n . This raises the possibility to use\n \n mi\n R<\/jats:styled-content>\n \u2010137\n <\/jats:italic>\n methylation as a biomarker for malignant prediction in patients with\n OLP<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/jop.12012","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T01:16:34Z","timestamp":1352078194000},"page":"315-321","source":"Crossref","is-referenced-by-count":64,"title":["Micro\n RNA<\/scp>\n \u2010137 promoter methylation in oral lichen planus and oral squamous cell carcinoma"],"prefix":"10.1111","volume":"42","author":[{"given":"Jun","family":"Dang","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Stomatology, Fourth Military Medical University Xi'an China"},{"name":"Department of Stomatology Affiliated Hospital of the Academy of Military Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Qian","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of General Surgery Xijing Hospital, Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Yong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of General Surgery Xijing Hospital, Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Stomatology, Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang\u2010Ying","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Stomatology, Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Stomatology, Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Stomatology, Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Kjems","sequence":"additional","affiliation":[{"name":"The Interdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Gao","sequence":"additional","affiliation":[{"name":"The Interdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin\u2010Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine School of Stomatology, Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.05.016"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.004"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/joms.2000.16629"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2008.01441.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.06.076"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1080\/00015550510036676","article-title":"Premalignant nature of oral lichen planus","volume":"85","author":"Laeijendecker R","year":"2005","journal-title":"Acta Derm 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