{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:44:21Z","timestamp":1788871461921,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,11,17]],"date-time":"2012-11-17T00:00:00Z","timestamp":1353110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["30772442"],"award-info":[{"award-number":["30772442"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"Postdoctoral Science Foundation of China","doi-asserted-by":"crossref","award":["2012M511877"],"award-info":[{"award-number":["2012M511877"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,4]]},"abstract":"\n Background<\/jats:title>\n \n The changes in\n N<\/jats:styled-content>\n otch signaling are closely related to the occurrence and development of many cancers. We have investigated Notch signaling receptor and its ligand expressions in TSCC cell lines, tissues and its significance. We clarified Notch signaling pathway in TSCC and its mechanism. We regulated\n N<\/jats:styled-content>\n otch signaling pathway of tumor cells, thereby inhibiting tumor cell proliferation and differentiation.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We detected\n J<\/jats:styled-content>\n agged1 protein and\n mRNA<\/jats:styled-content>\n expression levels in specimens (tongue cancer and adjacent tissues) from 74 patients with tongue cancer and in\n TSCC<\/jats:styled-content>\n cell line. The\n J<\/jats:styled-content>\n agged1\u2010targeted lentiviral vector\n RNA<\/jats:styled-content>\n i system was constructed, and its suppressive effects on the proliferation and invasion of tongue carcinoma cells in\n in vivo<\/jats:italic>\n and\n ex vivo<\/jats:italic>\n were determined.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Jagged1 was expressed in tongue squamous cell cancer tissues and cell line, but there were differences in its expression. Jagged1 was knocked down and the tumor growth was inhibited accompanying cell cycle changes. Animal studies also showed that the tumor growth was inhibited.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Jagged1 may be involved in the differentiation and proliferation of tongue cancer. Targeting\n J<\/jats:styled-content>\n agged1\n RNA<\/jats:styled-content>\n interference lentiviral vector can effectively lower\n J<\/jats:styled-content>\n agged1\n mRNA<\/jats:styled-content>\n and protein expression levels of\n T<\/jats:styled-content>\n ca8113 cells, thereby preventing the proliferation of\n TSCC<\/jats:styled-content>\n cells. Jagged1 is expected to be a promising new target for curing tongue cancer. In\u2010depth study of the interaction between\n J<\/jats:styled-content>\n agged1 and other molecules of\n N<\/jats:styled-content>\n otch signaling pathway in the process of carcinogenesis has important theoretical guidance and clinical significance in revealing the mechanism of\n J<\/jats:styled-content>\n agged1 and its application in the therapy for tongue cancer.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jop.12013","type":"journal-article","created":{"date-parts":[[2012,11,18]],"date-time":"2012-11-18T20:22:40Z","timestamp":1353270160000},"page":"322-331","source":"Crossref","is-referenced-by-count":11,"title":["Suppression of tongue squamous cell carcinoma growth by inhibition of\n J<\/scp>\n agged1\n in vitro<\/i>\n and\n in vivo<\/i>"],"prefix":"10.1111","volume":"42","author":[{"given":"Tong\u2010han","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Stomatology Affiliated Zhongshan Hospital Sun Yat\u2010sen University Zhongshan 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