{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T21:36:48Z","timestamp":1774733808367,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,10,27]],"date-time":"2012-10-27T00:00:00Z","timestamp":1351296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"crossref","award":["R21DE018714"],"award-info":[{"award-number":["R21DE018714"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"crossref","award":["R03DE016356"],"award-info":[{"award-number":["R03DE016356"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"crossref","award":["NCRR"],"award-info":[{"award-number":["NCRR"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"crossref","award":["M011RR000082"],"award-info":[{"award-number":["M011RR000082"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000072","name":"NIDCR","doi-asserted-by":"crossref","award":["UL1RR029890"],"award-info":[{"award-number":["UL1RR029890"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NCTAS","award":["UL1TR000064"],"award-info":[{"award-number":["UL1TR000064"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent aphthous stomatitis (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>) is characterized by painful recurrent oral ulcers and is typically diagnosed via history and clinical examination. Our aim was to validate a set of anamnestic diagnostic criteria (<jats:styled-content style=\"fixed-case\">RASDX<\/jats:styled-content>) to increase the accuracy of <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> diagnosis, particularly when a clinical examination is not feasible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants were enrolled during an unmatched case\u2013control study. <jats:styled-content style=\"fixed-case\">RASDX<\/jats:styled-content> consisted of an initial phone screening using standardized questionnaires and recognition of <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> photographs in the clinic. The proportion of agreement with an examination by an oral medicine expert was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 115 participants were scheduled for a clinical diagnostic visit and 11 were withdrawn. The remaining 104 participants were aged 18\u201350\u00a0years, 54% women, 64% <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>hite and 20% <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ispanic. Of these, all 49 controls with negative <jats:styled-content style=\"fixed-case\">RASDX<\/jats:styled-content> had no clinical ulcers. Of the 54 cases diagnosed with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> by <jats:styled-content style=\"fixed-case\">RASDX<\/jats:styled-content>, 53 were clinically confirmed to have <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> lesions (99% agreement; exact one\u2010sided 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a095\u2013100%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RASDX<\/jats:styled-content>, based on a combination of history and photograph recognition, was highly accurate compared with a diagnosis that employed an oral examination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12015","type":"journal-article","created":{"date-parts":[[2012,10,27]],"date-time":"2012-10-27T10:51:45Z","timestamp":1351335105000},"page":"290-294","source":"Crossref","is-referenced-by-count":12,"title":["Validation of anamnestic diagnostic criteria for recurrent aphthous stomatitis"],"prefix":"10.1111","volume":"42","author":[{"given":"Lorena","family":"Baccaglini","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Nebraska Medical Center Omaha NE USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas W.","family":"Theriaque","sequence":"additional","affiliation":[{"name":"Regulatory Knowledge and Research Support Clinical and Translational Science Institute University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan J.","family":"Shuster","sequence":"additional","affiliation":[{"name":"Health Outcomes and Policy College of Medicine University of Florida Gainesville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle","family":"Serrano","sequence":"additional","affiliation":[{"name":"College of Graduate Studies University of Central Florida Orlando FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajesh V.","family":"Lalla","sequence":"additional","affiliation":[{"name":"Section of Oral Medicine University of Connecticut Health Center Farmington CT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01143.x"},{"key":"e_1_2_5_3_1","first-page":"627","article-title":"Prevalence of recurrent herpes labialis and aphthous ulcers among young adults on six continents","volume":"113","author":"Embil JA","year":"1975","journal-title":"Can Med Assoc J"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1994.tb01815.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2004.00241.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04169.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016358509046497"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705223362103"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90031-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01840.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2009.00867.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2003.0134"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2011.01102.x"},{"key":"e_1_2_5_14_1","first-page":"685","article-title":"Oral health in America: a report of the Surgeon General","volume":"28","author":"Anonymous","year":"2000","journal-title":"J Calif Dent Assoc"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(97)80017-X"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1991.tb00952.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2005.00632.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2011.01900.x"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12015","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T16:01:58Z","timestamp":1700668918000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,27]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/jop.12015"],"URL":"https:\/\/doi.org\/10.1111\/jop.12015","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,27]]}}}