{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T23:06:59Z","timestamp":1781996819859,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,17]],"date-time":"2012-11-17T00:00:00Z","timestamp":1353110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to analyze the oral lesions of chronic paracoccidioidomycosis concerning their histomorphometric, immunohistochemical, and clinical features in a standardized sample.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty biopsy specimens of oral lesions of chronic paracoccidioidomycosis were submitted to hematoxylin and eosin (<jats:styled-content style=\"fixed-case\">H&amp;E<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>rocott\u2013<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>omori and immunohistochemical staining. Data regarding disease duration and size and number of oral lesions, as well as erythrocytes, leukocytes, lymphocytes, hematocrit, hemoglobin, and erythrocyte sedimentation rate, were collected from medical charts. Granuloma density and number and diameter of buds and fungal cells, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010gamma expression, as well as clinical and hematological features, were quantified and correlated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bud diameter was significantly greater in intermediate density granulomas compared to higher density granulomas. The other variables (number of buds, number and diameter of fungi, expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20102, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha and <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010gamma, and clinical and hematological features) did not significantly change with the density of granulomas. There was a positive correlation between bud number and fungal cell number (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.834), bud diameter and fungal cell diameter (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.496), erythrocytes and number of fungi (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.420), erythrocytes and bud number (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.408), and leukocytes and bud number (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.396). Negative correlation occurred between number and diameter of fungi (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.419), bud diameter and granuloma density (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.367), <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha expression and number of fungi (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.372), and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha expression and bud number (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.300).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The histological, immunological, and clinical features of oral lesions evaluated did not differ significantly between patients in our sample of chronic paracoccidioidomycosis. <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010alpha levels were inversely correlated with intensity of infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12018","type":"journal-article","created":{"date-parts":[[2012,11,19]],"date-time":"2012-11-19T01:22:59Z","timestamp":1353288179000},"page":"235-242","source":"Crossref","is-referenced-by-count":8,"title":["Interrelationship of clinical, histomorphometric and immunohistochemical features of oral lesions in chronic paracoccidioidomycosis"],"prefix":"10.1111","volume":"42","author":[{"given":"Mariana \u00c0.","family":"de Abreu e Silva","sequence":"first","affiliation":[{"name":"Postgraduate Program of Dental College Pontifical Catholic University of Rio Grande do Sul \u2013 PUCRS Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda G.","family":"Salum","sequence":"additional","affiliation":[{"name":"Postgraduate Program of Dental College Pontifical Catholic University of Rio Grande do Sul \u2013 PUCRS Porto Alegre RS 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