{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:07:51Z","timestamp":1770437271588,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,11,15]],"date-time":"2012-11-15T00:00:00Z","timestamp":1352937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this preliminary study was analyze the possible alterations in some salivary interleukins, usually associated with the inflammatory processes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The study comprised three groups: group 1, with 26 cases with bisphosphonates\u2010related osteonecrosis of the jaws (<jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>). Group 2, with 29 patients who had received <jats:styled-content style=\"fixed-case\">iBF<\/jats:styled-content> but without <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>. Group 3, with 26 control patients not treated with <jats:styled-content style=\"fixed-case\">BF<\/jats:styled-content> and without oral lesions.<\/jats:p><jats:p>We collected unstimulated whole saliva in all groups. A semiquantitative study was performed based on a cytokine array panel. We used the proteome profiler array for the study. We analyzed: Interleukin 1 alpha (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b1), interleukin\u20101 receptor antagonist (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>), and interleukin 1 beta (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found higher salivary values for all the cytokines studied in group 1 than in group 2 and 3. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 showed the major differences compared with control group. (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This preliminary study confirms that there are alterations in these interleukins in patients with <jats:styled-content style=\"fixed-case\">BRONJ<\/jats:styled-content>. These results give support to further additional salivary studies on these biomarkers by quantitative measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12021","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T00:31:10Z","timestamp":1353025870000},"page":"405-408","source":"Crossref","is-referenced-by-count":25,"title":["Bisphosphonates\u2010related osteonecrosis of the jaws: a preliminary study of salivary interleukins"],"prefix":"10.1111","volume":"42","author":[{"given":"Jose","family":"Bagan","sequence":"first","affiliation":[{"name":"Oral Medicine Stomatology and Maxillofacial Surgery Valencia University University General Hospital Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chirag C.","family":"Sheth","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Faculty of Health Sciences CEU University Cardenal Herrera Valencia 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