{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T16:23:04Z","timestamp":1770481384310,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T00:00:00Z","timestamp":1357689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The National Institute of Health Research Comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust"},{"name":"Kings College London, UK"},{"name":"Kings College London"},{"DOI":"10.13039\/501100000380","name":"Guy's and St Thomas' Charity","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000380","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Orofacial granulomatosis (<jats:styled-content style=\"fixed-case\">OFG<\/jats:styled-content>) is a chronic granulomatous condition of the mouth, face and lips. Recent work demonstrates a high rate of atopy and silver birch sensitisation from skin prick testing (<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>). Oral allergy syndrome (<jats:styled-content style=\"fixed-case\">OAS<\/jats:styled-content>) is an acute oro\u2010pharyngeal<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>mediated reaction, triggered by foods that cross react with pollens, most commonly silver birch. The aim of this study was to determine if patients with<jats:styled-content style=\"fixed-case\">OFG<\/jats:styled-content>and positive<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>to common<jats:styled-content style=\"fixed-case\">OAS<\/jats:styled-content>associated pollens responded to avoidance of cross reactive foods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with<jats:styled-content style=\"fixed-case\">OFG<\/jats:styled-content>and positive<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>to silver birch, grass, mugwort, ragweed and latex were required to avoid cross reacting foods, for 6\u00a0weeks and, in those who responded, for a total of 12\u00a0weeks. All had standardized oral examinations and were given severity scores (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>) at each appointment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty two of 47 (47%) patients had one or more positive<jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>and 13\/22 completed 6\u00a0weeks on the diet. No difference was seen in<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>between weeks 0 (14.62\u00a0\u00b1\u00a011.16) and 6 (13.31\u00a0\u00b1\u00a010.33;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.656). Six of 14 (43%) had significantly improved<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>(week 0; 19.17\u00a0\u00b1\u00a012.95, week 6; 10.83\u00a0\u00b1\u00a04.99,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.027). Five completed 12\u00a0weeks and no further improvement was seen (week 6; 11\u00a0\u00b1\u00a05.57, week 12; 10.4\u00a0\u00b1\u00a09.94;<jats:italic>P<\/jats:italic>\u00a0=\u00a00.068). Two patients required no further treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>On an intention to treat basis, only 2\/14 patients improved and required no further intervention. Whilst this diet cannot be recommended routinely, the improvement seen in some patients raises questions about the role of<jats:styled-content style=\"fixed-case\">OAS<\/jats:styled-content>in patients with<jats:styled-content style=\"fixed-case\">OFG<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12041","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T18:26:31Z","timestamp":1357755991000},"page":"517-522","source":"Crossref","is-referenced-by-count":23,"title":["Dietary intervention for oral allergy syndrome as a treatment in orofacial granulomatosis: a new approach?"],"prefix":"10.1111","volume":"42","author":[{"given":"H.","family":"Campbell","sequence":"first","affiliation":[{"name":"Diabetes and Nutritional Sciences Division King's College London (KCL) London UK"},{"name":"Department of Nutrition and Dietetics Guy's and St Thomas' NHS Foundation Trust (GSTFT) London UK"},{"name":"National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre at GSTFT and KCL London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P.","family":"Escudier","sequence":"additional","affiliation":[{"name":"King's College London Dental Institute London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Brostoff","sequence":"additional","affiliation":[{"name":"Diabetes and Nutritional Sciences Division King's College London (KCL) London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology GSTFT London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Milligan","sequence":"additional","affiliation":[{"name":"Diabetes and Nutritional Sciences Division King's College London (KCL) London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Challacombe","sequence":"additional","affiliation":[{"name":"King's College London Dental Institute London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Sanderson","sequence":"additional","affiliation":[{"name":"Diabetes and Nutritional Sciences Division King's College London (KCL) London UK"},{"name":"Department of Gastroenterology GSTFT London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C. E.","family":"Lomer","sequence":"additional","affiliation":[{"name":"Diabetes and Nutritional Sciences Division King's College London (KCL) London UK"},{"name":"Department of Nutrition and Dietetics Guy's and St Thomas' NHS Foundation Trust (GSTFT) London UK"},{"name":"Department of Gastroenterology GSTFT London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,9]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"101","article-title":"Oro\u2010facial granulomatosis\u2010a clinical and pathological analysis","volume":"54","author":"Wiesenfeld D","year":"1985","journal-title":"Q J Med"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200606000-00011"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-199X(97)90034-8"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-277X.1997.00490.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05921.x"},{"key":"e_1_2_5_7_1","first-page":"447","article-title":"Food intolerance in patients with oro\u2010facial granulomatosis","volume":"40","author":"Haworth RJ","year":"1986","journal-title":"Hum Nutr Appl Nutr"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.1002\/j.1536-4801.2006.tb01653.x","article-title":"Orofacial granulomatosis is a separate entity of Crohn's disease comprising and allergic component","volume":"42","author":"Kiparissi F","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"e_1_2_5_9_1","first-page":"78","author":"Mehta A","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1990.tb02123.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/93.8.507"},{"key":"e_1_2_5_12_1","first-page":"29","article-title":"Oro\u2010facial granulomatosis and clinical atopy","volume":"41","author":"James J","year":"1986","journal-title":"J Oral Med"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090502"},{"issue":"1","key":"e_1_2_5_14_1","first-page":"A99","article-title":"Allergy in orofacial granulomatosis and inflammatory bowel disease","volume":"59","author":"Patel P","year":"2010","journal-title":"Gut"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03759.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00976.x"},{"key":"e_1_2_5_17_1","unstructured":"PatelP.A study into the immunopathogenesis of orofacial granulomatosis. 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