{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:53:17Z","timestamp":1770749597996,"version":"3.50.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T00:00:00Z","timestamp":1357689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oral Pathology Medicine"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Serum homocysteine level is a biomarker of cardiovascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 399 primary and secondary burning mouth syndrome (<jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content>) patients without or with hematinic deficiencies were treated with vitamin <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> capsules plus none, one, or two deficient hematinics depending on the corresponding deficiency statuses of the patients. One hundred and seventy\u2010seven patients showed complete remission of all oral symptoms after treatment. The blood homocysteine, vitamin B12, folic acid, iron, and hemoglobin concentrations at baseline and after treatment till all oral symptoms had disappeared in these 177 complete\u2010response <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> patients were measured and compared by paired <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> patients with concomitant deficiencies of vitamin B12 only (<jats:italic>n<\/jats:italic>\u00a0=\u00a048), folic acid only (<jats:italic>n<\/jats:italic>\u00a0=\u00a012), vitamin B12 plus folic acid (<jats:italic>n<\/jats:italic>\u00a0=\u00a09), or vitamin B12 plus iron (<jats:italic>n<\/jats:italic>\u00a0=\u00a015), supplementations with vitamin <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> capsules plus corresponding deficient hematinics could significantly reduce the abnormally high serum homocysteine levels to normal levels after a mean treatment period of 5.4\u20138.2\u00a0months (all <jats:italic>P<\/jats:italic>\u2010values\u00a0&lt;\u00a00.01). For <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> patients without definite hematinic deficiencies (<jats:italic>n<\/jats:italic>\u00a0=\u00a062), supplementation with vitamin <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> capsules only could also significantly decrease the relatively higher homocysteine levels to significantly lower levels after a mean treatment period of 10.2\u00a0months (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Specific supplementations with vitamin <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> capsules plus none or corresponding deficient vitamin B12 and\/or folic acid can reduce the abnormally high serum homocysteine levels to normal levels in <jats:styled-content style=\"fixed-case\">BMS<\/jats:styled-content> patients without or with deficiencies of corresponding hematinics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12043","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T18:31:35Z","timestamp":1357756295000},"page":"474-479","source":"Crossref","is-referenced-by-count":80,"title":["Significant reduction of serum homocysteine level and oral symptoms after different vitamin\u2010supplement treatments in patients with burning mouth syndrome"],"prefix":"10.1111","volume":"42","author":[{"given":"Andy","family":"Sun","sequence":"first","affiliation":[{"name":"Graduate Institute of Clinical Dentistry School of Dentistry, National Taiwan University Taipei Taiwan"},{"name":"School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital, College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung\u2010Pin","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Dentistry School of Dentistry, National Taiwan University Taipei Taiwan"},{"name":"School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital, College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Dentistry School of Dentistry, National Taiwan University Taipei Taiwan"},{"name":"School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital, College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital, College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Oral Biology School of Dentistry, National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Jung","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital, College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Pin","family":"Chiang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Dentistry School of Dentistry, National Taiwan University Taipei Taiwan"},{"name":"School of Dentistry National Taiwan University Taipei Taiwan"},{"name":"Department of Dentistry National Taiwan University Hospital, College of Medicine National Taiwan University Taipei Taiwan"},{"name":"Graduate Institute of Oral Biology School of Dentistry, National Taiwan University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,9]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"Oral and maxillofacial pathology","author":"Neville BW","year":"2009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.15.e562"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130301400405"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.16.e144"},{"key":"e_1_2_5_6_1","first-page":"b146","article-title":"Diagnostic dilemma: the enigma of an oral burning sensation","volume":"77","author":"Klasser GD","year":"2011","journal-title":"J Can Dent Assoc"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-64402007000400013"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.09.008"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2012.02.022"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060900"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.1.193"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804093381507"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.53.6.731"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197409122911101"},{"key":"e_1_2_5_15_1","first-page":"979","article-title":"Vitamin B12 deficiency","volume":"67","author":"Oh RC","year":"2003","journal-title":"Am Fam Phys"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90149-X"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292S129"},{"key":"e_1_2_5_18_1","first-page":"2455","article-title":"Microcytic anemia","volume":"55","author":"Shine JW","year":"1997","journal-title":"Am Fam Physician"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.6.3867"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2009.10718101"},{"key":"e_1_2_5_21_1","first-page":"e470","article-title":"Burning mouth disorder (bmd) and taste: a hypothesis","volume":"13","author":"Femiano F","year":"2008","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_5_22_1","first-page":"163","article-title":"Clinical and biological features associated with taste loss in internal medicine patients","volume":"44","author":"Kettaneh A","year":"2005","journal-title":"A cross\u2010sectional study of 100 cases. Appetite"}],"container-title":["Journal of Oral Pathology &amp; Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12043","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjop.12043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jop.12043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T19:20:05Z","timestamp":1696188005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jop.12043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,9]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/jop.12043"],"URL":"https:\/\/doi.org\/10.1111\/jop.12043","archive":["Portico"],"relation":{},"ISSN":["0904-2512","1600-0714"],"issn-type":[{"value":"0904-2512","type":"print"},{"value":"1600-0714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,9]]}}}