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The genetics mechanism of expression level of inflammatory factors is not clear in <jats:styled-content style=\"fixed-case\">ROU<\/jats:styled-content>, but from genetics the expression level of inflammatory factors at least partly depend on the gene polymorphisms. Therfore, we decided to investigate inflammatory factors gene polymorphism and its association with the susceptibility of recurrent oral ulceration in Chinese.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genomic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was obtained from 42 subjects with recurrent oral ulceration, 86 subjects of healthy control individuals.Genotypes and alleles of 10 genes and 17 polymorphisms sites were analyzed by Mass\u2010<jats:styled-content style=\"fixed-case\">ARRAY<\/jats:styled-content> Analyzer method. Then, the differences in distribution of each genotype and allele were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The statistical differences in distribution of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 (rs1800629 and rs1800630) genotype and allele were observed among the groups with recurrent oral ulceration and healthy control individuals (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), while <jats:styled-content style=\"fixed-case\">VEGFA<\/jats:styled-content> (rs1570360, rs833061, and rs2010963), <jats:styled-content style=\"fixed-case\">EGF<\/jats:styled-content> (rs4444903), <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> (rs361525), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>10 (rs1800896, rs1800872), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>2 (rs2069762), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>4 (rs2243250), Fas (rs1800682, rs2234767), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>12A (rs2243115, rs568408), <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>12B (rs3212227), and <jats:styled-content style=\"fixed-case\">IFNG<\/jats:styled-content> (rs2430561) showed no statistical differences of genotype and allele in controls as compared to those in patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that the <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 (rs1800629 and rs1800630) genotype is an indicator for the susceptibility of recurrent oral ulceration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jop.12048","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T08:08:40Z","timestamp":1360829320000},"page":"528-534","source":"Crossref","is-referenced-by-count":11,"title":["Inflammatory factors gene polymorphism in recurrent oral ulceration"],"prefix":"10.1111","volume":"42","author":[{"given":"Mao","family":"Sun","sequence":"first","affiliation":[{"name":"Center for DNA Typing Fourth Military Medical University Xi'an China"},{"name":"Department of Biochemistry and Molecular Biology Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan\u2010Min","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Fourth Military Medical University Xi'an China"},{"name":"School of Stomatology Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Ying","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Medicine Fourth Military Medical University Xi'an China"},{"name":"School of Stomatology Fourth Military Medical University Xi'an 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